2023
DOI: 10.1177/09603271231215499
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Integrative analysis of renal microRNA and mRNA to identify hub genes and pivotal pathways associated with cyclosporine-induced acute kidney injury in mice

Qiaoling Yang,
Xunjiang Wang,
Hongjing Li
et al.

Abstract: Cyclosporine (CsA) is an immunosuppressive agent that often causes acute kidney injury (AKI) in children. The specific mechanisms underlying CsA-induced AKI are currently unknown. This study used an integrated network analysis of microRNA (miRNA) and mRNA expression profiles, biochemical and pathological analyses to further investigate these potential mechanisms of CsA-induced AKI. Small RNA sequence analysis identified 25 differentially expressed miRNAs, RNA sequencing analysis identified 4,109 differentially… Show more

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“…Also, Zbp1 regulates innate immune-mediated inflammatory cell death, particularly through macrophages ( 76 ). Myd88 expression in macrophage pathways is differentially enriched in scaffold implants during ACAR and has been shown to be critical to both toll-like receptor functions in allograft rejection ( 77 ) and calcineurin inhibitor–induced acute kidney injury ( 78 ). As calcineurin inhibition is the primary clinical strategy for maintaining immune quiescence posttransplant, the scaffold implant should be investigated further as a tool to monitor suppression effectiveness.…”
Section: Discussionmentioning
confidence: 99%
“…Also, Zbp1 regulates innate immune-mediated inflammatory cell death, particularly through macrophages ( 76 ). Myd88 expression in macrophage pathways is differentially enriched in scaffold implants during ACAR and has been shown to be critical to both toll-like receptor functions in allograft rejection ( 77 ) and calcineurin inhibitor–induced acute kidney injury ( 78 ). As calcineurin inhibition is the primary clinical strategy for maintaining immune quiescence posttransplant, the scaffold implant should be investigated further as a tool to monitor suppression effectiveness.…”
Section: Discussionmentioning
confidence: 99%