2022
DOI: 10.1038/s41598-022-10662-6
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Integrative analysis of TCGA data identifies miRNAs as drug-specific survival biomarkers

Abstract: Biomarkers predictive of drug-specific outcomes are important tools for personalized medicine. In this study, we present an integrative analysis to identify miRNAs that are predictive of drug-specific survival outcome in cancer. Using the clinical data from TCGA, we defined subsets of cancer patients who suffered from the same cancer and received the same drug treatment, which we call cancer-drug groups. We then used the miRNA expression data in TCGA to evaluate each miRNA’s ability to predict the survival out… Show more

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“…It is especially suited for identifying biomarkers predictive of drug response because the molecular assays are performed on pre-treatment samples, representing the state of a tumor at the point when treatment decisions are made. Our group has previously identified molecular features associated with drug-specific survival using the TCGA gene expression, 29 copy number variation, 30,31 protein, 32 and miRNA 33 datasets. While the high dimensionality of the methylation dataset makes it the most challenging to analyze, the promise that DNA methylation holds as a source of biomarkers as well as our success with these other molecular data types make it a critical dataset to explore for molecular features related to drug efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…It is especially suited for identifying biomarkers predictive of drug response because the molecular assays are performed on pre-treatment samples, representing the state of a tumor at the point when treatment decisions are made. Our group has previously identified molecular features associated with drug-specific survival using the TCGA gene expression, 29 copy number variation, 30,31 protein, 32 and miRNA 33 datasets. While the high dimensionality of the methylation dataset makes it the most challenging to analyze, the promise that DNA methylation holds as a source of biomarkers as well as our success with these other molecular data types make it a critical dataset to explore for molecular features related to drug efficacy.…”
Section: Introductionmentioning
confidence: 99%