2020
DOI: 10.1016/j.neuron.2019.11.012
|View full text |Cite
|
Sign up to set email alerts
|

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

Abstract: Highlights d Precision functional mapping identifies subcortical integration zones in individuals d Systematic connectivity reveals motor, cognitive, and visual attention integration zones d Subcortical functional organization has individually variable and conserved features d Integration zones map onto variably effective DBS sites, suggesting clinical utility

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

19
182
1

Year Published

2020
2020
2023
2023

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 188 publications
(211 citation statements)
references
References 147 publications
(223 reference statements)
19
182
1
Order By: Relevance
“…While the field of precision fMRI has recently emerged in human brain research 4,7,12,33,34 , rodent data are still analyzed at the group level 35,36 . A major challenge in precision fMRI is the need of large amount of data per subject ranging from 50 to 100 minutes based on the studied brain structure 37 .…”
Section: Discussionmentioning
confidence: 99%
“…While the field of precision fMRI has recently emerged in human brain research 4,7,12,33,34 , rodent data are still analyzed at the group level 35,36 . A major challenge in precision fMRI is the need of large amount of data per subject ranging from 50 to 100 minutes based on the studied brain structure 37 .…”
Section: Discussionmentioning
confidence: 99%
“…Doing so in each patient that undergoes DBS surgery is impractical and would be very demanding for patients. However, the dataset was recently used to investigate individualized vs. group-level connectivity-based DBS targets (Greene et al, 2019). Similarly, 45 of the 1200 human connectome project participants were scanned twice to allow for quantification of retest error (Van Essen et al, 2013).…”
Section: Pros and Cons Of Normative Vs Patient-specific Connectivitymentioning
confidence: 99%
“…Furthermore, the adaptability of ACLS could help to individualize treatments. Recent work suggests that the efficacy of deep-brain stimulation depends on physiological differences between patients and the exact placement of stimulating electrodes (Greene et al, 2020;Horn, 2019). The adaptability of ACLS could allow for a greater number of electrodes to be implanted, with the system searching for the optimal stimulation pattern across those electrodes.…”
Section: Clinical Applications Of Aclsmentioning
confidence: 99%
“…The localization of cognitive function varies significantly between individual mice, monkeys, and humans. This changes the effect of stimulation across subjects and can determine the efficacy of deep brain stimulation treatments (Greene et al, 2020). Individual differences in disease progression also mean the effect of stimulation will change over time in a unique way for each patient (Blauwendraat et al, 2017).…”
Section: Introductionmentioning
confidence: 99%