Integrative approaches to computational biomedicine

Coveney, Peter V.; Díaz‐Zuccarini, Vanessa; Graf, Norbert; Hunter, Peter; Kohl, Peter; Tegnér, Jesper; Viceconti, Marco

doi:10.1098/rsfs.2013.0003

Cited by 11 publications

(12 citation statements)

References 18 publications

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“…Health is an issue of many tissues working together in the right ways, that is, proteins have to be active in the appropriate compartment and at the right time. The Virtual Physiological Human (VPH) initiative is promoting this line of thought for very good reasons: Most of the functioning of the human may be determined at the physiological rather than the molecular level [7].…”

Section: And the Scientific Base?mentioning

confidence: 99%

Systems Pharmacology: An opinion on how to turn the impossible into grand challenges

Westerhoff

Nakayama²,

Mondeel

et al. 2015

Drug Discovery Today: Technologies

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Section: And the Scientific Base?mentioning

confidence: 99%

Systems Pharmacology: An opinion on how to turn the impossible into grand challenges

Westerhoff

Nakayama²,

Mondeel

et al. 2015

Drug Discovery Today: Technologies

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“…Understanding genetic variation is one of the keys to the development of personalized medicine. It is clear that genetic as well as phenotypic differences must be included in any patient-specific models (Coveney et al, 2013).…”

Section: A Translation To the Growth Of Humansmentioning

confidence: 99%

Growth Pattern of Animals Is a Model for the Growth of Humans

Stass¹

2021

JMR

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The aim of this research was to translate a reading of a growth model of pigs to the modelling of growth of humans. The growth of individuals in the studied species is both a species-specific and phenotype-dependant process. The process is known as ontogenesis and has been considered as a dynamic system. The method used in the study was mathematical modelling. A hybrid model of animal's growth was applied to the experimental evidence to produce a reading of the growth dynamic. In the study, an earlier formulated analytical model of pig growth was developed to analyse a possible translation to the growth of humans. The study implies that in animals, the growth trajectory is phenotype-dependant, nonlinear and discontinuous. In some aspects such as saltatory growth and longevity as well as the discontinuous dynamic of the growth trajectory the translation of the results for the modelling the growth of humans were discussed.

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“…Finally, recent efforts on multi-scale models of organs attempt to bridge the gap between molecular pathways and physiology through projects such as the Virtual Physiological Human [45] and the Virtual Liver, a collaborative effort to produce a physiological model of the liver that interacts with pathways and other molecular component in order to support simulations and the understanding of the liver function in health and disease [46]. Such efforts are still in their initial steps but have the potential to facilitate a better understanding of the relationship between genes and phenotypes.…”

Section: Linking Pathways To Phenotypesmentioning

confidence: 99%

Linking gene expression to phenotypes via pathway information

2015

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Establishing robust links among gene expression, pathways and phenotypes is critical for understanding diseases and developing treatments. In recent years there have been many efforts to develop the computational means to traverse from genes to gene expression, model pathways and classify phenotypes. Numerous ontologies and other controlled vocabularies have been developed, as well as computational methods to combine and mine these data sets and establish connections. Here we discuss these efforts and identify areas of future work that could lead to a better integration of genes, pathways and phenotypes to provide insights into the mechanisms under which gene mutations affect expression and pathways and how these effects are manifested onto the phenotype.Electronic supplementary materialThe online version of this article (doi:10.1186/s13326-015-0013-5) contains supplementary material, which is available to authorized users.

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Integrative approaches to computational biomedicine

Cited by 11 publications

References 18 publications

Systems Pharmacology: An opinion on how to turn the impossible into grand challenges

Systems Pharmacology: An opinion on how to turn the impossible into grand challenges

Growth Pattern of Animals Is a Model for the Growth of Humans

Linking gene expression to phenotypes via pathway information

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