2019
DOI: 10.1016/j.bbrc.2018.12.152
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Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation

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Cited by 7 publications
(5 citation statements)
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“…CFTR knockdown with shRNA has also been reported to increase the expression of the EGFR ligand epiregulin (EREG) at the gene and protein level in the intestinal epithelial cell line Caco‐2, 61 however we did not detect any differences in this EGFR ligand in either of our experimental systems at least at the transcription level. Others have reported that AREG is markedly increased by WT‐CFTR at the transcription level via the long intergenic non‐coding RNA SUMF1‐2, 62 which is contradictory to our findings. Future studies will be necessary to understand this difference, but it is likely due to differences in the experimental systems used.…”
Section: Discussioncontrasting
confidence: 99%
“…CFTR knockdown with shRNA has also been reported to increase the expression of the EGFR ligand epiregulin (EREG) at the gene and protein level in the intestinal epithelial cell line Caco‐2, 61 however we did not detect any differences in this EGFR ligand in either of our experimental systems at least at the transcription level. Others have reported that AREG is markedly increased by WT‐CFTR at the transcription level via the long intergenic non‐coding RNA SUMF1‐2, 62 which is contradictory to our findings. Future studies will be necessary to understand this difference, but it is likely due to differences in the experimental systems used.…”
Section: Discussioncontrasting
confidence: 99%
“…Likewise, Kamei and colleagues analyzed the expression of non-coding genes, or functional RNAs with no protein-coding capacity [68]. Using the Human Transcriptome Array, 91 dysregulated non-coding RNAs were identified in the CFBE41o-cell line.…”
Section: Non-coding Rna Profilingmentioning
confidence: 99%
“…In addition, a recent study utilizing transcriptome profiling by microarray identified 91 ncRNAs dysregulated in CF airway epithelial cells. Further mechanistic analyses indicated linc-SUMF1-2 was associated with the aberrant expression of genes such as MYC and CXCL10 in CF airway epithelial cells [67].…”
Section: Emerging Targets For Transcriptome Profilingmentioning
confidence: 99%