Integrative medicine and the nutrition transition: What we learn from history and how it can be applied?

Spedding, Simon; Best, Talitha

doi:10.1016/j.aimed.2014.12.006

Cited by 2 publications

(2 citation statements)

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“…Vitamin D is commonly known as a fat‐soluble hormone. Vitamin D 2 (ergocalciferol) and Vitamin D 3 (cholecalciferol) are biologically inert precursors or prohormones that function in a similar manner to 25‐hydroxyvitamin D (25(OD) D 6 . In a comparison study as well as a randomized control trial it was found that there is a greater incidence of vitamin D deficiencies in PD, demonstrating the negative association between serum levels of 25‐hydroxyvitamin D regarding the prevalence of PD 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D is commonly known as a fat-soluble hormone. Vitamin D 2 (ergocalciferol) and Vitamin D 3 (cholecalciferol) are biologically inert precursors or prohormones that function in a similar manner to 25-hydroxyvitamin D (25(OD) D. 6 In a comparison study as well as a randomized control trial it was found that there is a greater incidence of vitamin D deficiencies in PD, demonstrating the negative association between serum levels of 25-hydroxyvitamin D regarding the prevalence of PD. 7 Many animal model studies have revealed that vitamin D has a significant impact on the extent of toxininduced loss of dopaminergic fibers, ignoring very high serum vitamin D concentrations or excessively high serum vitamin D amplification in mice, which increases the neurotoxic effects.…”

Section: Introductionmentioning

confidence: 99%

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Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson's disease

Marshal

Kuriakose

Alhazmi

et al. 2023

J of Cellular Biochemistry

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Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects dopaminergic neurons in the midbrain. A recent study suggests that Orphan Nuclear Receptor 1 (NURR1) impairment may contribute to PD pathogenesis. Our study found three potent agonists for NURR1 protein based on structural and ligand-based screening methods. The pharmacophore is comprised of a hydrogen bond donor, a hydrophobic group, and two aromatic rings (DHRR). The Pharmacophore screening method screened 3142 compounds, of which 3 were screened using structure-based screening. An analysis of the molecules using Molecular Mechanics-Generalized Born Surface Area (binding free energy) revealed a range of −46.77 to −59.06 Kcal/mol. After that, chemical reactivity was investigated by density functional theory, and molecular dynamics simulation was performed (protein-ligand stability). Based on the computational studies, Lifechemical_16901310, Maybridge_2815310, and NPACT_392450 are promising agonists with respect to NURR1. To confirm the potency of the identified compounds, further validation and experiments must be conducted.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%