Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue

Kirby, Tyler J.; Walton, R. Grace; Finlin, Brian S.; Zhu, Beibei; Ünal, Reşat; Rasouli, Neda; Peterson, Charlotte A.; Kern, Philip A.

doi:10.1152/physiolgenomics.00071.2015

Cited by 20 publications

(17 citation statements)

References 48 publications

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“…Even though software systems rely on consensus concepts of both structural features of miRNAs and molecular bases of miRNA-mRNA interaction, they apply different algorithms, which can give largely discordant results and should be addressed (3). Second, knowledge of the role of miRNAs in the regulation of insulin secretion and action is emerging mostly from experiments in animal models and will undoubtedly keep improving with paralleled genome-wide expression profiling data sets of miRNAs and mRNAs (36). However, a critical issue with miRNA studies in model systems lies in the potential conservation of DNA sequences of both miRNAs and their binding sites across species (23).…”

Section: Discussionmentioning

confidence: 99%

Biological roles of microRNAs in the control of insulin secretion and action

Caldérari

Diawara

Garaud

et al. 2017

Physiological Genomics

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microRNAs (miRNAs) are intracellular and circulating molecular components contributing to genome expression control through binding mRNA targets, which generally results in downregulated mRNA expression. One miRNA can target several mRNAs, and one transcript can be targeted by several miRNAs, resulting in complex fine-tuning of regulation of gene networks and signaling pathways. miRNAs regulate metabolism, adipocyte differentiation, pancreatic development, β-cell mass, insulin biosynthesis, secretion, and signaling, and their role in diabetes and obesity is emerging. Their pathophysiological effects are essentially dependent on cellular coexpression with their mRNA targets, which can show tissue-specific transcriptional responses to disease conditions and environmental challenges. Current knowledge of miRNA biology and their impact on the pathogenesis of diabetes and obesity is based on experimental data documenting miRNA expression generally in single tissue types that can be correlated with expression of target mRNAs to integrate miRNA in functional pathways and gene networks. Here we present results from the most significant studies dealing with miRNA function in liver, fat, skeletal muscle, and endocrine pancreas and their implication in diabetes and obesity

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Section: Discussionmentioning

confidence: 99%

Biological roles of microRNAs in the control of insulin secretion and action

Caldérari

Diawara

Garaud

et al. 2017

Physiological Genomics

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“…Seventeen miRNAs are differentially expressed in the IR vs. IS group, including 16 miRNAs downregulated in IR individuals, such as miR-30b , and miR-145 . Correspondingly, the potential target genes of these miRNAs, i.e., ADAM22 , MYO5A , LOX and GM2A for miR-145 ; ADAM22 for miR-30b , were upregulated in IR subjects [62]. …”

Section: Systematic Analysis Of Mirna–mrna Regulatory Network In Dmentioning

confidence: 99%

Regulatory Roles of MicroRNAs in Diabetes

Feng

Xing

Xie

2016

IJMS

128

100

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MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus.

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“…It is concluded that the pipeline theoretically potentials to progress clinical controlling of both paediatric and adult malignant GCTs (Murray et al, 2016). Kirby et al (2016) suggested that use of bio-informatics incorporation of mRNA and microRNA arrays produces confirmable mRNA-microRNA pairs that are accompanying insulin resistance, and can be confirmed in vitro. In their study, an integrative mRNA-mi-RNA microarray method for the purpose of identifying putative molecular interactions that control the transcriptome in subcutaneous adipose tissue of insulin sensitive (IS) and insulin resistant (IR) people, has been used (Kirby et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Kirby et al (2016) suggested that use of bio-informatics incorporation of mRNA and microRNA arrays produces confirmable mRNA-microRNA pairs that are accompanying insulin resistance, and can be confirmed in vitro. In their study, an integrative mRNA-mi-RNA microarray method for the purpose of identifying putative molecular interactions that control the transcriptome in subcutaneous adipose tissue of insulin sensitive (IS) and insulin resistant (IR) people, has been used (Kirby et al, 2016). Seventeen mi-RNAs have been revealed that they are differentially expressed in insulin resistant (IR) versus insulin sensitive (IS).…”

Section: Introductionmentioning

confidence: 99%

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miRNA in Cancer Pathology

Alakeel¹,

Al-Doori

2017

JMBR

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MicroRNA/miRNA refers to types of RNA which are non-coding; they are21 to 25 nucleotides in length. In most cases, at particular nucleotide locations, they relate to one or more mRNAs. Deadenylation, cleavage, and alternative procedures of translation's suppression are the means by which miRNA disturb gene repression. Recent investigations seem to propose that miRNAs are involved in many cell procedures and for this they became perfect targets for usage in healing purposes. Various miRNAs are involved in the development of human vascular diseases, due to their function in modulating vascular cell proliferation, differentiation, migration and apoptosis via their targeted genes. Since vascular diseases are multifactorial and complex, numerous genes may be involved in their progression and regulation. Therefore, miRNAs can also have multiple gene targets, and in some instances, one gene can be modulated by various miRNAs. As of now, more than 800 human microRNAs have been identified using miBase, and work is still being conducted to search for and characterize new miRNAs. With rigorous clinical and fundamental studies, a clear understanding of how miRNAs function, in addition to the ways they can be used as biomarkers and targets for cancer and cardiovascular illnesses, will progress.

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Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue

Abstract: . Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue.

Cited by 20 publications

References 48 publications

Biological roles of microRNAs in the control of insulin secretion and action

Biological roles of microRNAs in the control of insulin secretion and action

Regulatory Roles of MicroRNAs in Diabetes

miRNA in Cancer Pathology

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