2020
DOI: 10.1101/2020.02.17.952135
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

Abstract: The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear model-based methods which may fail to account for complex structure and interrelationships within molecular datasets. Therefore, in this study, we perform genome-and epigenome-wide association studies (GWAS/EWAS) on the levels of 70 plasma-derived inflammatory protein biomarkers in healthy older adults (… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
9
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
3
2

Relationship

4
1

Authors

Journals

citations
Cited by 5 publications
(9 citation statements)
references
References 59 publications
0
9
0
Order By: Relevance
“…For BayesR+ GWAS data, see https://datashare.is. ed.ac.uk/handle/10283/3673; https://doi.org/10.7488/ds/2854 [102]. For OLS regression EWAS data, see https://datashare.is.ed.ac.uk/handle/10283/3628, https://doi.org/10.7488/ds/2818 [103].…”
Section: Availability Of Data and Materialsmentioning
confidence: 99%
See 2 more Smart Citations
“…For BayesR+ GWAS data, see https://datashare.is. ed.ac.uk/handle/10283/3673; https://doi.org/10.7488/ds/2854 [102]. For OLS regression EWAS data, see https://datashare.is.ed.ac.uk/handle/10283/3628, https://doi.org/10.7488/ds/2818 [103].…”
Section: Availability Of Data and Materialsmentioning
confidence: 99%
“…For OLS regression EWAS data, see https://datashare.is.ed.ac.uk/handle/10283/3628, https://doi.org/10.7488/ds/2818 [103]. For OSCA EWAS data, see https:// datashare.is.ed.ac.uk/handle/10283/3627, https://doi.org/10.7488/ds/2817 [104]. For BayesR+ EWAS data, see https://datashare.is.ed.ac.uk/handle/102 83/3626; https://doi.org/10.7488/ds/2816 [105].…”
Section: Availability Of Data and Materialsmentioning
confidence: 99%
See 1 more Smart Citation
“…BMI, six metre walk time, and units of alcohol were log transformed to reduce skew -a constant of one was added to the alcohol units prior to transforming. An Olink panel of inflammation-related proteins[37], measured on blood samples at age 70 years in LBC1936, were related to both EpiScore g and measured g in age-and sex-adjusted linear regression models. An additional panel of Olink neurology-related proteins[16,37], measured on blood samples at age 73 years in LBC1936, were related to EpiScore g, access protocol[39].…”
mentioning
confidence: 99%
“…An Olink panel of inflammation-related proteins[37], measured on blood samples at age 70 years in LBC1936, were related to both EpiScore g and measured g in age-and sex-adjusted linear regression models. An additional panel of Olink neurology-related proteins[16,37], measured on blood samples at age 73 years in LBC1936, were related to EpiScore g, access protocol[39]. A 1.5 T GE Signa HDx clinical scanner (General Electric, Milwaukee, WI, USA) was used to collect structural T1-(voxel size = 1 × 1 × 1.3 mm), T2-(voxel size =…”
mentioning
confidence: 99%