Integrative Role of Albumin: Evolutionary, Biochemical and Pathophysiological Aspects

Belinskaia, Daria A.; Voronina, Polina A.; Гончаров, Н. В.

doi:10.1134/s002209302106020x

Cited by 33 publications

(20 citation statements)

References 214 publications

(256 reference statements)

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“…The concentration of serum, or plasma proteins reflects metabolism and immunity status of the body, therefore it has a great potential and used as biomarkers for different health conditions (14) .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Air Pollution Exposure on The Different Serum and Saliva Proteins Levels: A Pilot Study on The Workers at HFO Combustion Unit in AL- Dora Electricity Station/ Baghdad, Iraq

Ahmed¹,

Hasan²

2023

The Egyptian Journal of Hospital Medicine

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Background: Many studies reported that exposure to hazardous air conditions such as chemicals, fumes, diesel exhaust affects human health and become a major concern globally. Body proteins play central roles in cell structure and functions. Aim: Although exposure to such exposure at the workplace has negative effects on health. This pilot study aimed to follow the changes in the total protein [T], albumin [A], globulin [G], and [A/ G] ratio in the sera and saliva samples of workers who are exposed to the fume emitted from heavy fuel oil (HFO) combustion unit. Participants and Methods: Workers (N=59) at the heavy fuel oil combustion unit in electricity station of Al-Dora station/ Baghdad/ Iraq and 53 unexposed age and gender matched healthy individuals were the participants of this study. The levels of serum and salivary total proteins and albumin were measured, and the level of globulins and albumin / globulin ratio were calculated. Results: There were variations in both serum and salivary total protein [TP], albumin [A], globulin [G] and [A]/ [G]ratio between that of the workers group and the control healthy group. The impact of the fume combustion on the studied biochemical parameters were further analyzed based on the workers age, period of their service, smoking habit and using of safety equipment. Conclusion:The results of this pilot study showed that the impact of the air pollution resulted from the HFO combustion on salivary [TP], [A], [G] and [A]/ [G] ratio was more than that on the serum of the workers' group.

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Section: Discussionmentioning

confidence: 99%

The Effects of Air Pollution Exposure on The Different Serum and Saliva Proteins Levels: A Pilot Study on The Workers at HFO Combustion Unit in AL- Dora Electricity Station/ Baghdad, Iraq

Ahmed¹,

Hasan²

2023

The Egyptian Journal of Hospital Medicine

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“…It may be hypothesized that the tolerant mink were genetically capable of suppressing production of GLO after infection. Despite significant differences in the concentrations of GLO and TP among tolerant groups, the concentrations of ALB were comparable among tolerant groups, a result of the balancing effect of ALB in maintaining the colloidal osmotic pressure of the blood [ 101 ]. The linear and significant increases in the A/G ratio, which was parallel to the increasing tolerance ancestry, resulted from decreasing GLO and no change in ALB concentration by increasing tolerance ancestry.…”

Section: Discussionmentioning

confidence: 99%

“…The negative correlation coefficients between GLO and ALB in the current (−0.10) and a previous study (−0.29) [ 14 ], is the result of decreased ALB concentration after increased ꝩ-GLO [ 68 ] or GLO concentrations [ 33 ] in AMDV infected mink. This finding was a result of diminished ALB synthesis by the liver to maintain blood colloidal osmotic pressure (reviewed in [ 101 ]). In an earlier study in AMDV inoculated mink [ 14 ], ALB concentration had a negative and mostly non-significant Spearman rank correlation with BUN, CREA, GLO, ALKP, and GGT (−0.02 to 0.29).…”

Section: Discussionmentioning

confidence: 99%

Serum Analytes of American Mink (Neovison Vison) Challenged with Aleutian Mink Disease Virus

Farid

Rupasinghe

2022

Animals

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Black American mink (Neovison vison), which had been selected for tolerance to Aleutian mink disease virus (AMDV) for more than 20 years (TG100) or were from herds that have been free of AMDV (TG0), along with their progeny and crosses with 50% and 75% tolerance ancestry, were inoculated with a local isolate of AMDV. Blood samples were collected from 493 mink between 120 and 1211 days post-inoculation, and concentrations of 14 serum analytes were measured. Distributions of all analytes significantly deviated from normality, and data were analyzed after Box–Cox power transformation. Significant differences were observed among tolerant groups in the concentrations of globulin (GLO), total protein (TP), alkaline phosphatase, urea nitrogen, and calcium. Concentrations of GLO and TP linearly and significantly decreased with an increasing percentage of tolerance ancestry. Eleven analytes had the smallest values in the tolerant groups (TG100 or TG75), and eight analytes had the greatest values in the non-selected groups (TG0 or TG50). Antibody titer had the greatest correlation coefficients with GLO (0.62), TP (0.53), and creatinine (0.36). It was concluded that selection for tolerance decreased the concentrations of most serum analytes, and TP and GLO were the most accurate biomarkers of tolerance to AMDV infection. Males had significantly greater values than females for phosphorus and total bilirubin concentrations, but females had significantly greater amylase, cholesterol, and BUN concentrations than males.

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“…Serum albumin is a protein produced by the liver, which plays a role in maintaining plasma colloid osmotic pressure, participating in redox reactions in vivo , maintaining capillary permeability, and controlling cell apoptosis ( 33 , 34 ). It is also an indicator of nutritional and inflammatory status ( 35 , 36 ).…”

Section: Discussionmentioning

confidence: 99%

Distinct Age-Related Clinical Features and Risk Assessment in Chinese With Chronic Lymphocytic Leukemia

et al. 2022

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The biological and clinical features of chronic lymphocytic leukemia (CLL) exhibited profound heterogeneity across Chinese and patients of predominately European descent. However, the age-related peculiarities and risk assessment of Chinese CLL patients remained ill-defined. The present study demonstrated that CLL patients were characterized by the earlier age at onset in China (median age at diagnosis: 63 years old) than in the United States (median age at diagnosis: 69 years old). Young patients from Shandong Provincial Hospital CLL database displayed prolonged overall survival than the Surveillance, Epidemiology, and End Results cohort. Furthermore, among Chinese CLL patients, young patients showed an increased relapse rate compared with elderly patients. To optimize the risk assessment of CLL patients, novel risk score models named PR-Score and HBG-Score were developed for predicting the outcomes of young and elderly CLL patients respectively. The neonatal survival prediction systems were superior to international prognostic index for CLL (CLL-IPI) and Binet stage in assessing the overall survival and progression free survival of CLL patients. The analyses highlighted refinement of risk evaluation for CLL patients in different age groups, providing insights into individualized diagnosis and treatment of CLL.

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Integrative Role of Albumin: Evolutionary, Biochemical and Pathophysiological Aspects

Cited by 33 publications

References 214 publications

The Effects of Air Pollution Exposure on The Different Serum and Saliva Proteins Levels: A Pilot Study on The Workers at HFO Combustion Unit in AL- Dora Electricity Station/ Baghdad, Iraq

The Effects of Air Pollution Exposure on The Different Serum and Saliva Proteins Levels: A Pilot Study on The Workers at HFO Combustion Unit in AL- Dora Electricity Station/ Baghdad, Iraq

Serum Analytes of American Mink (Neovison Vison) Challenged with Aleutian Mink Disease Virus

Distinct Age-Related Clinical Features and Risk Assessment in Chinese With Chronic Lymphocytic Leukemia

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