2023
DOI: 10.2139/ssrn.4361624
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Integrative Single-Cell Meta-Analysis Reveals Disease-Relevant Vascular Cell States and Markers in Human Atherosclerosis

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Cited by 4 publications
(15 citation statements)
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References 117 publications
(243 reference statements)
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“…Furthermore, the migration and transition from VMSC towards fibromyocytes has been reported previously 33 . Hence, we reasoned that the migration could occur with a cellular transition and analyzed the VSMC cluster for a potential trajectory ( Fig.…”
Section: Resultsmentioning
confidence: 56%
See 1 more Smart Citation
“…Furthermore, the migration and transition from VMSC towards fibromyocytes has been reported previously 33 . Hence, we reasoned that the migration could occur with a cellular transition and analyzed the VSMC cluster for a potential trajectory ( Fig.…”
Section: Resultsmentioning
confidence: 56%
“…Investigation of integrated datasets has unraveled the dynamics of modulated SMC phenotypes in atherosclerosis 33 . We elaborated on it and demonstrated that VSMC can act as a signal mediator to luminal fibromyocytes as well as adventitial fibroblasts and we showed a spatial trajectory indicating migration and transition of VSMC into fibromyocytes and in the case of atherosclerosis a progression toward a fibroblast-like expression state of the fibromyocytes.…”
Section: Discussionmentioning
confidence: 99%
“…Development of atherosclerosis (AS) and the process of plaque formation involve the participation of various cell types [23]. In this study, we initiated an investigation into the distinctions among different cell types during AS development by integrating two single-cell sequencing datasets (GSE155512 and GSE159677).…”
Section: Single-cell Data Integration and Revealed Cellular Heterogen...mentioning
confidence: 99%
“…Based on the existing literature reporting scRNA-seq of whole blood vessels, ECs represent only 5-15% of the entire population (30)(31)(32)(33)(34). To enrich ECs and capture the EC-interacting cells (esp.…”
Section: Profiling the Diabetic Transcriptome In Human Mesenteric Intimamentioning
confidence: 99%
“…As a result, monocytes (if present, would be differentiating) and MΦ are not distinguished, and thus named collectively as mononuclear phagocytes (MPs). Annotation of all intima scRNA-seq cells using reported cell type marker genes (31,32,34) identified 6 major cell types as visualized on uniform manifold approximation and projection (UMAP): ECs (~30%, consisting of 2 clusters), MPs (~26%, consisting of 5 clusters), T/NK cells (~33%, consisting of 5 clusters), fibroblasts/VSMC (7%, consisting of 2 subclusters), and others (e.g., B cells, and mast cells) (Fig. 1D-E).…”
Section: Profiling the Diabetic Transcriptome In Human Mesenteric Intimamentioning
confidence: 99%