Amblyceps crassioris, a new species of amblycipitid catfish, is described from the Mahanadi River basin in Odisha, India. The new species can be distinguished from its congeners in having a combination of the following characters: a deeply forked caudal fin, centrally projecting hooks on proximal lepidotrichia of median caudal‐fin rays absent, jaws equal in length, lateral line absent, body depth at anus 15.1%–19.5% standard length (SL), caudal peduncle depth 13.0%–18.3% SL, adipose‐fin base length 21.1%–27.1% SL, eye diameter 7.35%–14.1% head length and 38 total vertebrae.