2023
DOI: 10.15283/ijsc22209
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Integrin α4 Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction

Zihui Yuan,
Juan Tan,
Jian Wang

Abstract: The efficacy of adipose-derived stem cells (ASCs) on myocardial infarction is limited due to poor survival and engraftment. Integrin-mediated cell adhesion is a prerequisite for its survival and homing. ASCs expressed insufficient integrin α 4 , limiting their homing capacity. This study aims to characterize integrin α 4 + ASC subpopulation and investigate their therapeutic efficacy in myocardial infarction. We used fluorescence-activated cell sorting … Show more

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