2023
DOI: 10.1186/s12964-023-01264-4
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Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

Siyi Li,
Chibuzo Sampson,
Changhao Liu
et al.

Abstract: Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain. While most integrins have a short cytoplasmic tail, integrin β4 has a long cytoplasmic tail that can indirectly interact with the actin cytoskeleton. Additionally, 'inside-out' signals can induce integrins to adopt a high-affinity extended conformation for their appropriate ligands. These properties enable integrins to transmit bidirectional ce… Show more

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Cited by 36 publications
(14 citation statements)
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“…Metastasis is a complex procedure involving the basement membrane's degradation, avoidance from the primary tumor, surviving in the circulatory system, colonizing, and increasing the targeted organ's parenchyma 82 . This research endeavored to examine the function of RGOH100 in the metastasis process by analyzing metastasis-related proteins such as matrix metalloproteinases (MMPs 2 and 9) and cell adhesion molecules (CAMs) (ICAM, VCAM).…”
Section: Resultsmentioning
confidence: 99%
“…Metastasis is a complex procedure involving the basement membrane's degradation, avoidance from the primary tumor, surviving in the circulatory system, colonizing, and increasing the targeted organ's parenchyma 82 . This research endeavored to examine the function of RGOH100 in the metastasis process by analyzing metastasis-related proteins such as matrix metalloproteinases (MMPs 2 and 9) and cell adhesion molecules (CAMs) (ICAM, VCAM).…”
Section: Resultsmentioning
confidence: 99%
“…It is essential for tissue development, immunological responses, angiogenesis, wound healing, and the regulation of cell survival and proliferation. 55 The p38 pathway has been linked to macrophage-mediated inflammatory diseases. In particular, the p38 MAPKs are inflammatory mediators like cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α).…”
Section: Discussionmentioning
confidence: 99%
“…In this review, we elucidate our understanding of the characteristics, ligands, signaling pathways and biological functions of integrin β1, which can be classified into four receptors; namely, the RGD-binding receptors, leukocyte-specific receptors, laminin-binding receptors and collagen binding receptors according to the specificity of the ligands [ 102 ]. The current investigation provides evidence that the integrin β1–ECM interaction activates FAK, MAPK, PI3K-AKT, and other pathways for tumor growth, metastasis, invasion and angiogenesis [ 103 ].…”
Section: Discussionmentioning
confidence: 99%