Integrin α2 gene polymorphism is a risk factor of coronary artery lesions in Chinese children with Kawasaki disease

Abstract

Background Kawasaki disease (KD) is a systemic vasculitis, and the formation of coronary artery lesions(CAL) is its most common sequela. Both genetic and environmental factors are considered to be important factors of in KD. Integrin α2 (ITGA2) is a transmembrane receptor that is associated with susceptibility to several diseases, but its relevance to KD with CAL is unclear. Methods We genotyped ITGA2 rs1126643 in 785 KD patients with the CAL and no-CAL(NCAL) (300 patients with CAL, and 485 age- and sex-matched patients with NCAL). OR (95% CI) and adjusted OR (95% CI) were used to evaluate the intensity of the association. Results We found a significantly increased risk of KD with CAL associated with ITGA2 rs1126643 genotypes (CT vs CC: adjusted OR = 1.57, 95% CI = 1.16–2.12, P = 0.0032; CT/TT vs CC: adjusted OR = 1.49, 95% CI = 1.12–2.00, P = 0.0068; T vs C: adjusted OR = 1.66, 95% CI = 1.16–2.51, P = 0.0165). Moreover, we found that carriers of the CT/TT genotype had a significant risk of KD with coronary artery lesion susceptibility for children ≤60 months of age, and the CT/TT genotype was significantly associated with an increased risk of SCAL formation and MCAL formation when compared with the CC genotype. Conclusion ITGA2 rs1126643 was associated with increased susceptibility and severity of CAL in KD.

Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism

“…Обнаружен значительно повышенный риск БК с ПКА, связанный с генотипами ITGA2 rs1126643 (CT против CC, отношение шансов (ОШ) =1,57, доверительный интервал (ДИ): 1,16-2,12, p=0,0032; CT/TT vs CC: ОШ =1,49, ДИ: 1,12-2,00, p=0,0068; T vs C: ОШ =1,66, ДИ: 1,16-2,51, p=0,0165). Выявлено также, что носители генотипа CT/TT имели значительный риск БК с восприимчивостью к ПКА у детей в возрасте до 60 мес., а генотип CT/TT был достоверно связан с повышенным риском образования чешуек и ПКА по сравнению с генотипом CC [9]. Мутация C807 в гене ITGA2 связана с риском раннего инфаркта миокарда, ишемического инсульта, эмболии, тромбоза после ангиопластики и стентирования коронарных артерий.…”

Study Progress of Coronary Artery Damage in Kawasaki Disease

“…ITGA2 gene polymorphism is one of the important factors affecting CAL in children with KD combined with CAL, and the risk of KD combined with CAL associated with ITGA2rs1126643 genotype is significantly increased.Stratified analysis showed that ITGA2rs1126643 could inhibit the formation of coronary artery small aneurysms (SCAL) and coronary artery medium aneurysms (MCAL) induced by KD, among which, compared with rs1126643CC genotype, the harmful effects of CT/TT variant genotype were more obvious in children ≤60 months and men [31 ] .…”