Integrity of hypothalamic fibers and cognitive fatigue in multiple sclerosis

Hanken, Katrin; Eling, Paul; Kastrup, Andreas; Klein, Jan; Hildebrandt, Helmut

doi:10.1016/j.msard.2014.11.006

Cited by 31 publications

(29 citation statements)

References 37 publications

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“…Although the increased diffusivity in hypothala-musÀbrainstem fibres in MS patients without cognitive fatigue was found twice, in our first study [6] and now in this study, there are still important methodological problems that should be addressed in future studies. First, the specific localization of the vagal projections in the brainstem cannot be visualized by 3 T MRI scanners, nor is it possible to visualize the ARAS or the locus coeruleus or the raphe nucleus with 3 T MRI resolution.…”

Section: Discussionmentioning

confidence: 70%

On the relation between self‐reported cognitive fatigue and the posterior hypothalamic−brainstem network

Hanken

Manousi

Klein

et al. 2015

Euro J of Neurology

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Section: Discussionmentioning

confidence: 70%

On the relation between self‐reported cognitive fatigue and the posterior hypothalamic−brainstem network

Hanken

Manousi

Klein

et al. 2015

Euro J of Neurology

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“…Además, en la sustancia blanca se evidenciaron axones distróficos B. Pedraz, et al colecciones de macrófagos perivasculares en comparación con pacientes con EM sin este tipo de lesiones (p = 0,007) [25]. Basándonos en el estudio de Hanken et al, en el que se analizan las fibras hipotalámicas, hemos organizado una tabla (Tabla III) con la información más importante que muestra y fundamenta nuestra hipótesis anteriormente descrita [42].…”

Section: Tamaño De La Muestraunclassified

Importancia del glutamato en las funciones neuroendocrinológicas en la esclerosis múltiple relacionadas con la fatiga

Pedraz

Sammer²

2018

RevNeurol

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The importance of glutamate in the neuro-endocrinological functions in multiple sclerosis, related to fatigue Summary. Multiple sclerosis is an inflammatory disease, which still today affects the Northern-hemisphere population, generating a socioeconomically burden. One of the most unfavorable symptoms in this chronic disorder is fatigue. In this review, we favor and sustain a main alteration of the hypothalamus-pituitary-axis complex and its physiopathologic consequences, mostly related to glutamate and corticoid levels. We try to sustain our hypothesis in what is already reported, corroborating that the inflammatory cells release mainly glutamate, a neuro-toxic substance which leads to a demyelinating effect and as a main result fatigue as a symptom. When this hypothesis is demonstrated, we could trace therapeutic targets to stop the release of glutamate of these immunologic cells, in order to avoid fatigue in multiple sclerosis patients.

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“…Neben den oben genannten Regelkreisen haben einige Studien die Fatigue auch mit anderen Hirnstrukturen verknüpft. Eine Studie fand einen Zusammenhang zwischen Fatigue und veränderter Faserstruktur zwischen posteriorem Hippokampus und Mesenzephalon [82]. Dies stimmt mit den Ergebnissen zweier früherer Studien überein.…”

Section: Weitere Neuronale Korrelateunclassified

Fatigue bei Multipler Sklerose: Neuronale Korrelate und Möglichkeiten nicht-invasiver Hirnstimulation mit tDCS

Ayache

Chalah²,

Kümpfel

et al. 2017

Fortschr Neurol Psychiatr

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Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system and causes high rates of non-traumatic disability in young adults. Fatigue is frequently reported by a major part of patients during the disease course and dramatically increases the burden of illness. Despite the high prevalence of fatigue and its enormous impact on quality of life, its pathophysiological mechanisms are still unclear. Its etiology is multifactorial and complex, and is usually classified into 'primary' fatigue resulting from the pathological brain changes versus 'secondary' fatigue following disease symptoms, sleep disturbances, mood disorders, and side effects of medication. Hypotheses concerning the pathophysiology of this symptom are based on radiological, physiological, and endocrine data. It has been suggested that fatigue refers to structural and functional changes in a variety of neuronal networks. Over the past years, non-invasive brain stimulation methods were used to modulate brain function, especially transcranial direct current stimulation (tDCS) has proven to impact neuronal connectivity; however evidence is still sparse due to the pilot character of the studies. In this review we aim at discussing the neuronal correlates of fatigue and the potential influence of tDCS in the modulation of the symptoms.

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Integrity of hypothalamic fibers and cognitive fatigue in multiple sclerosis

Cited by 31 publications

References 37 publications

On the relation between self‐reported cognitive fatigue and the posterior hypothalamic−brainstem network

On the relation between self‐reported cognitive fatigue and the posterior hypothalamic−brainstem network

Importancia del glutamato en las funciones neuroendocrinológicas en la esclerosis múltiple relacionadas con la fatiga

Fatigue bei Multipler Sklerose: Neuronale Korrelate und Möglichkeiten nicht-invasiver Hirnstimulation mit tDCS

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