One key issue in the study of the structural integrity of smart structures is the research of high cyclic electro-mechanical (E/M) loading. To truly understand the integrity of smart structures, investigation must include active sensors/actuators embedded or bonded as a part of a smart structure, and to be loaded in a combined electro-mechanical cyclic loads as the way they will be used in real life applications. A better understanding of the effects of cyclic E/M loading is necessary to characterize the lifetime behavior of active ceramic components. The present research is a part of a comprehensive 1 experimental study dealing with the structural integrity of smart structures. A laminate composite made of graphite-epoxy with a quasi-isotropic lay-up was used as a host structure for all the specimens. Two commercially available piezoelectric patches (PZT-5H, lead zirconate titanate) were used: ACX patches from QP15N Cymer Inc. U.S.A. and PIC255 from PI Ceramics, Germany. The first part of the present study investigates the behaviour of piezolaminated beams with embedded or surface bonded patches, subjected to axial tension/compression loads. Seven different specimens (numbered as AX-EM) with embedded piezoceramic patches and another two specimens (numbered as AX-SM) with four piezoceramic patches bonded to the surface of each host structure (one pair of ACX and one pair of PIC-255 patches) were tested. The second part of the present study investigates the behaviour of seven specimens (numbered as BEN1-7) with four piezoelectric patches, one pair of ACX and one pair of PIC-255, bonded on each side of the host structure. These specimens were subjected to bending cyclic loads using four-point bending test setup. The degradation in the sensing abilities of the piezoelectric patches for an increasing number of E/M load cycles was monitored and recorded. The aim of the present research is to examine the changes in the piezoceramic sensing capabilities as a piezo-laminated structure is undergoing an increasing number of electro-mechanical load cycles. These two types of integrated loads, called Electro-Mechanical (E/M) loads can be applied in-phase (both loads cause either tension or compression) or out-of-phase (one load causes tension while the other causes compression and vice versa). It is expected that the main impact of the present research will be its capability to predict the structural integrity of a given smart structure as a function of its use, yielding a balanced design with an enhanced survivability and a higher confidence in the usage of piezoelectric patches.