Integrity of the Blood-Ocular Barrier After Intravitreal Gas Injection

Ogura, Yuichiro; Tsukada, Takako; Negi, Akira; Honda, Yoshio

doi:10.1097/00006982-198909030-00007

Cited by 12 publications

(2 citation statements)

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“…New non-invasive approaches, based on a biomechanical alteration of the vitreous gel, hold promise, as already indicated for the use of hyaluronidase in non-clearing vitreous hemorrhage. 7 The induced vitreous liquefaction [8][9][10][11][12][13][14] and blood-retinal barrier breakdown 10,15,16 associated with the use of expansive gases in vivo have led the authors to consider its therapeutic use in experimental vitreous hemorrhage. The purpose of this study was to evaluate the effectiveness of a single injection of an expanding gas in the vitreous cavity in order to accelerate the clearance rate in experimental vitreous hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

Intravitreal gas injection for the treatment of experimental vitreous hemorrhage in rabbits

Mello–Filho

Cardillo

Farah

et al. 2002

Current Eye Research

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Gas injection proved effective in the treatment of experimental vitreous hemorrhage. It was significantly better than the injection of balanced salt solution, according to criteria of extension, intensity, and clearing time. Its technical facility, lack of complications, and low cost encourage additional research into gas injection to add knowledge to this initial study and to clarify its potential usefulness to treat persistent vitreous hemorrhage as well as to elucidate some unique pathophysiology features of blood catabolism in the vitreous.

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Section: Introductionmentioning

confidence: 99%

Intravitreal gas injection for the treatment of experimental vitreous hemorrhage in rabbits

Mello–Filho

Cardillo

Farah

et al. 2002

Current Eye Research

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“…Dr. Heriot considers himself to be Bmad^, according to a 2014 interview with the BCentre for Eye Research Australia^ [4]. But after all it may be so, that the circumvention of a gas tamponade fosters persistent retinal reattachment and reduces the risk of PVR, since gas aggravates blood-ocular barrier breakdown [5].…”

mentioning

confidence: 99%

Vision or Madness? Primary vitrectomy without gas tamponade

Kirchhof

2016

Graefes Arch Clin Exp Ophthalmol

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Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

Mansour

Ferguson

Lucia

et al. 1991

Graefe's Arch Clin Exp Ophthalmol

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We investigated vitreous replacement by long-lasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P less than 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.

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Integrity of the Blood-Ocular Barrier After Intravitreal Gas Injection

Cited by 12 publications

References 0 publications

Intravitreal gas injection for the treatment of experimental vitreous hemorrhage in rabbits

Intravitreal gas injection for the treatment of experimental vitreous hemorrhage in rabbits

Vision or Madness? Primary vitrectomy without gas tamponade

Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

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