Intellectual functions in patients with lateralized frontal tumours.

Smith, Aaron

doi:10.1136/jnnp.29.1.52

Cited by 39 publications

(15 citation statements)

References 21 publications

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“…This pattern of lateralized differentiation was demonstrated not only for the summary W-B measures but also for the individual subtests. These results are in direct contrast to those of Smith (1966aSmith ( , 1966b. Although Smith used a brain tumor population, he studied a composite group of patients with tumors of varying pathological processes.…”

Section: Discussioncontrasting

confidence: 60%

Neuropsychological correlates of rapidly Vs. slowly growing intrinsic cerebral neoplasms

Hom

Reitan

1984

Journal of Clinical Neuropsychology

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Four groups of patients with intrinsic cerebral neoplasms were compared to determine the differential effect of neoplasm (rapidly vs. slowly growing) and lateralization of damage (right vs. left hemisphere) upon neuropsychological functioning. No prior study has had enough subjects with neoplastic lesions to permit this kind of investigation. The group with rapidly growing neoplasms consistently had greater neuropsychological impairment. Lateralization of cerebral damage was found to have a differential effect on neuropsychological functions. Results indicate that neuropathological and lateralization characteristics of neoplastic lesions (and probably of cerebral lesions in general) are important variables in understanding the behavioral correlates of cerebral damage.

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Section: Discussioncontrasting

confidence: 60%

Neuropsychological correlates of rapidly Vs. slowly growing intrinsic cerebral neoplasms

Hom

Reitan

1984

Journal of Clinical Neuropsychology

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“…It has been previously suggested that there may be a differential onset of seizures, dependent upon the lateralisation of the dysfunction (69). Furthermore, Smith (1966) examining the age at onset of left and right frontal lobe tumor cases in several studies (70,71), found consistently younger ages for those with left frontal tumors (72). Whether this is a consequence of pathophysiology of the tumor and lateralisation differences in the frontal regions (i.e., the left hemisphere being more susceptible), or the difference in ability to detect left frontal tumors (i.e., their effects being more obvious on clinical examination), is unclear.…”

Section: Discussionmentioning

confidence: 99%

Age at Onset and Neuropsychological Function in Frontal Lobe Epilepsy

Upton

Thompson

1997

Epilepsia

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Summary:Purpose: Previous studies into the cognitive consequences of frontal lobe epileptic dysfunction may have proved inconclusive, due to a factor not commonly accounted for: Damage or disturbance during different epochs of development may give rise to different levels of neuropsychological dysfunction. In this study, we investigated the influence of age at onset on cognitive performance in a group of subjects with frontal lobe epilepsy (FLE).Methods: Seventy-four subjects (42 with left, and 32 with right) FLE were classified into early (0-6 years), intermediate (7-1 1 years) or late onset (212 years) and their performance recorded on a battery of measures assessing both executive and motor skills.Results: On the measures of executive functioning, no consistent pattern emerged, whereas on the measures of motor skill, the results suggested that a right-sided early onset (i.e., 0-6 years) did not impair performance compared to a later lesion within the same hemisphere. Furthermore, this sparing of performance was not observed within the left hemisphere.Conclusions: Overall, the results suggest that individuals with differing ages of epilepsy onset will be differentially impaired on certain cognitive tasks. Several tentative ramifications of these results are suggested.

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“…This is followed by the expected severe left hemiplegia and hemianopia but ability to walk was often acquired, and some patients developed useful movement of the left arm. The greater reluctancetoremovethe lefthemisphere in adults reflects widespread beliefs that the integrity of various dominant hemisphere structures is necesary for many functions including receptive and expressive language (oral and written), 'higher' mental functions (Smith, 1966), control of right and left-sided purposeful movements (Liepmann, 1905), arithmetical reasoning, and discrimination of colours (Hecaen and Ajuriaguerra, 1964). Numerous cases with left-sided focal lesions have been cited to support these beliefs.…”

mentioning

confidence: 99%