Intellectual outcome at 12 years of age in congenital hypothyroidism

Salerno, M.; Militerni, Roberto; Maio, Salvatore Di; Bravaccio, Carmela; Gasparini, N; Tenore, Alfred

doi:10.1530/eje.0.1410105

Cited by 70 publications

(64 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to our findings, some studies have reported an association between endocrinological parameters throughout childhood and intellectual outcome (10,13) and language performance (11). However, in these studies initial treatment regimen consisted of late and low-dose substitution therapy (10,11,13). This suggests that cerebral injury occurs not only prenatally, but may continue postnatally if initial therapy regimen consists of late and low-dose treatment.…”

Section: Discussioncontrasting

confidence: 99%

“…Children with athyreosis had lower IQ than those with dysgenesis. This is in line with earlier studies (10,13). In addition, among all neonatal variables, only pretreatment T4 levels were associated with outcome.…”

Section: Discussionsupporting

confidence: 92%

“…Interestingly, two studies on intellectual outcome in adolescence after a late and/or low-dose initial treatment reported comparable intellectual outcome to our findings (FSIQ 102.4 and 101.6, respectively) (11,12). Another study reported considerably lower mean IQ levels both in the CH and in the sibling control group (FSIQ 88.4 for CH group, 91.8 for controls, respectively) with similar initial treatment (13). IQ deficits in all three studies ranged between 6 and 9 IQ scores.…”

Section: Discussionmentioning

confidence: 78%

See 2 more Smart Citations

Children With Congenital Hypothyroidism: Long-Term Intellectual Outcome After Early High-Dose Treatment

et al. 2009

View full text Add to dashboard Cite

ABSTRACT:We aim to determine long-term intellectual outcome of adolescents with early high-dose treated congenital hypothyroidism (CH). Sixty-three prospectively followed children with CH were assessed at age of 14 y with the Wechsler Intelligence Scale for Children-Revised and compared with 175 healthy controls. Median age at onset of treatment was 9 d (range 5-18 d) and median starting dose of levothyroxine (L-T4) was 14.7 g/kg/d (range 9.9 -23.6 g/kg/d). Full-scale intelligence quotient (IQ) was significantly lower than in controls after adjustment for socioeconomic status (SES) and gender (101.7 versus 111.4; p Ͻ 0.0001). Children with athyreosis had a lower performance IQ than those with dysgenesis (adjusted difference 7.6 IQ scores, p Ͻ 0.05). Lower initial thyroxine (T4) levels correlated with poorer IQ (r ϭ 0.27, p ϭ 0.04). Lower SES was associated with poorer IQ, in particular in children with CH (interaction, p ϭ 0.03). Treatment during childhood was not related to IQ at age 14 y. Adolescents with CH manifest IQ deficits when compared with their peers despite early high-dose treatment and optimal substitution therapy throughout childhood. Those adolescents with athyreosis and lower SES are at particular risk for adverse outcome. Therefore, early detection of intellectual deficits is mandatory in children with CH. (Pediatr Res 65: 242-248, 2009)

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 78%

See 1 more Smart Citation

Children With Congenital Hypothyroidism: Long-Term Intellectual Outcome After Early High-Dose Treatment

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In children with congenital hypothyroidism who receive substitutive L-T 4 treatment within the first weeks of life, a rapid normalization of TSH levels seems to be associated with a higher intelligence quotient (IQ) later in life. Furthermore, poor compliance to the therapy, documented by increased levels of TSH in the presence of normal levels of thyroid hormone, has been associated with lower intellectual performance and decreased visual-spatial ability (12).…”

Section: Introductionmentioning

confidence: 99%

Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism

Cerbone

Bravaccio²,

Capalbo³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. The aim of this cross-sectional, controlled study was to evaluate growth and intellectual outcome in children with persistent SH who have never been treated with levothyroxine. Design and methods: Clinical and auxological parameters, thyroid function, and intellectual outcome were evaluated in 36 children with persistent SH at the age of 9.7G0.6 (range 4-18.0) years. Children had been followed longitudinally for 3.3G0.3 (range 2.0-9.3) years, from first diagnosis of SH until enrollment in the study. Thirty-six age-and sex-matched children were enrolled in the study as controls. Results: At study entry, height (K0.8G0.2 SDS), bone age/chronological age (BA/CA ratio 0.92 G0.6), and body mass index (BMI K0.1G0.2 SDS) in SH children were normal. Despite long-term duration of SH, none of these parameters showed a worsening with respect to height (K0.7G0.2 SDS), BA/CA (0.97G0.03), and BMI (K0.1G0.2) at the time of first SH detection. None of the children showed overt signs or symptoms of hypothyroidism during the follow-up. Verbal (99.1G2.2), performance (100.4G1.9), and full-scale (99.7G1.9) intelligence quotient (IQ) scores in SH children were normal and comparable to those of controls. No relationship was detected between IQ scores and the degree or duration of SH. Conclusions: Persistent SH in children is not associated with alterations in growth, bone maturation, BMI, and cognitive function or other complaints that could be ascribed to SH even after several years without therapeutic intervention.

show abstract

“…However, previous studies have indicated that children who receive early treatment for CH have a normal intelligence quotient combined with attention problems (2,3), motor deficits and defects in visuospatial skills, language and memory (4,5). Several studies have correlated these problems with the severity of CH and others with the timing in starting treatment (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Bisacchi¹,

Bal²,

Nardi³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To compare the psychological adjustment and behaviour of congenital hypothyroidism (CH) children and their parents with a control group. Study design: A cross-sectional study was carried out with 84 CH subjects diagnosed by neonatal screening (range 2.7-18.6 years), subdivided into four age groups: group 1 (2-5 years); group 2 (6-10 years); group 3 (11-13 years); and group 4 (14-18 years) and was compared with an age-matched control group. Patients were assessed using two questionnaires: Child Behaviour Checklist for parents and Youth Self-Report for children over 11 years of age. Results: In groups 1, 3 and 4, total score (TS), internalising score (ISZproblems within the self) and externalising score (ESZconflicts with other people) as reported by parents were not significantly different in CH patients and in controls. In group 2, parents of CH children showed values of TS (P!0.05), IS (P!0.05), ES (P!0.05) and scores on other scales significantly higher than controls. In self-reports of groups 3 and 4, the behavioural scales were not significantly different in CH patients and in controls. Conclusions: Paediatricians should be informed about the increased risk of the development of behavioural problems at primary school age in CH patients. At this age special attention should be paid to parental worries and anxiety. However, it can be reassuring for the patients and parents to know that the problems may be related to CH, and that they may spontaneously disappear.

show abstract

Intellectual outcome at 12 years of age in congenital hypothyroidism

Cited by 70 publications

References 17 publications

Children With Congenital Hypothyroidism: Long-Term Intellectual Outcome After Early High-Dose Treatment

Children With Congenital Hypothyroidism: Long-Term Intellectual Outcome After Early High-Dose Treatment

Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism

Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Contact Info

Product

Resources

About