Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age- and sex-related differences

Weid, Nicolas von der; Mosimann, I; Hirt, Andreas; Wacker, Pierre; Beck, Martín; Imbach, Paul; Caflisch, Ueli; Niggli, Felix; Feldges, A; Wagner, Hans-Peter

doi:10.1016/s0959-8049(02)00260-5

Cited by 142 publications

(145 citation statements)

References 21 publications

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“…Although age at diagnosis as a predictor of pursuit accuracy and of pursuit stability does not reach significance in our study, our finding of a trend level effect suggests that a young age at diagnosis as a risk factor for worse visuomotor performance in survivors of ALL may be worthy of further study. This association would be in accordance with previous studies that report a younger age at diagnosis as a risk factor for worse cognitive performance in survivors of ALL (Copeland et al, 1996;Von der Weid et al, 2003), suggesting a greater vulnerability of less mature brain structures to neurotoxic insult (Ciesielski et al, 1999).…”

Section: Discussionsupporting

confidence: 93%

“…Step 3 Greater vulnerability of girls to chemotherapy-induced central neurotoxic effects of chemotherapy has been noted in several studies on neuropsychological sequelae of ALL treatment (Brown et al, 1998;Von der Weid et al, 2003;Waber et al, 1992). Notably, in a behavioral study in rats, female animals were more sensitive to the effects of therapies involving methotrexate than males (Mullenix et al, 1994).…”

Section: Discussionmentioning

confidence: 94%

“…As risk factors for poorer cognitive performance after childhood ALL treated with chemotherapy only, female gender (Brown et al, 1998;Von der Weid et al, 2003;Waber et al, 1992) and a young age at diagnosis (Copeland et al, 1996;Von der Weid et al, 2003) have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Buizer

Sonneville

Heuvel‐Eibrink

et al. 2005

J. Inter. Neuropsych. Soc.

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Treatment for childhood acute lymphoblastic leukemia (ALL), which includes CNS prophylaxis, is associated with central and peripheral neurotoxicity. The purpose of the present study was to analyze the effects of chemotherapy on various levels of visuomotor control in survivors of childhood ALL treated without cranial irradiation, and to identify risk factors for possible deficits. Visuomotor function was compared between children after treatment for ALL (n 5 34), children after treatment for Wilms tumor, which consists of non-CNS directed chemotherapy (n 5 38), and healthy controls (n 5 151). Three tasks were administered: a simple visual reaction time task and two tasks measuring visuomotor control with one requiring a higher level of cognitive control than the other. Visuomotor deficits were detected only in the ALL group, with poorer performance restricted to the condition requiring the highest level of control. Significant risk factors for poorer performance were female gender and a short time since end of treatment, and a trend was found for a young age at diagnosis. A high cumulative methotrexate dose was an adverse predictive factor in girls. The results indicate that chemotherapy-induced central neurotoxicity in childhood ALL treatment is associated with higher order visuomotor control deficits. Girls appear to be particularly vulnerable. (JINS, 2005, 11, 554-565.)

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

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Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Buizer

Sonneville

Heuvel‐Eibrink

et al. 2005

J. Inter. Neuropsych. Soc.

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“…Th e authors of clinical studies indicate that females have a higher risk of neurocognitive complications aft er therapy ALL [26][27][28], which was not the case in this study-complications were equally represented and in male and female patients. According to the results of other authors, dexamethasone more often causes psychiatric disorders compared to prednisone, primarily due to the greater liposolubility which increased the crossing of blood-brain barrier [29].…”

Section: Discussionmentioning

confidence: 47%

Safety and tolerability of high doses of glucocorticoides

Rakić¹,

Kolarovic²,

Konstantinidis³

et al. 2016

Hosp Pharm Int Multi J

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SUMMARYIntroduction: Treatment of acute lymphoblastic leukemia includes the use of high doses of glucocorticoides (prednisone and dexamethasone), which signifi cantly increase the success of therapy due to lymphocytolitic eff ect. The aim: The aim of the study was to determine tolerability of high doses of prednisone and dexamethasone in children with acute lymphoblastic leukemia and the structure and the intensity of adverse eff ects, occurred after application of these medicines. Subjects and methods:In a prospective study, we analyzed adverse eff ects of high doses of glucocorticoides in children suff ering acute lymphoblastic leukemia treated in the Institute for Child and Youth Health Care of Vojvodina, since December 2010. until October 2014, were analyzed. This study included 18 patients, aged from 2 to 15 years. Results: Hyperglycemia appeared in 89% of patients treated with prednisone and in 61% of patients treated with dexamethasone. In order to control the high blood glucose level (above 10 mmol /L), in 11% of patients insulin was used. Hypertension appeared in 28% patients treated with prednisone and dexamethasone. Antihypertensives were needed for regulation in 17% patients. Hypopotassemia and hypocalcaemia were signifi cantly more expressed after the use of prednisone in comparison to dexamethasone. In 11% of patients, the treatment with dexamethasone caused depressive behavior, followed by agitation. Conclusion: Adverse eff ects of dexamethasone and prednisone, administered in high doses in children with ALL were known, expected and reversible. Adverse reactions usually disappeared spontaneously or after short-term symptomatic therapy.

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“…Des informations détaillées concernant la mé-thodologie et les résultats du RSCE peuvent être consultés sur le site web du RSCE (www.kinder krebsregister.ch), ainsi que dans les rapports annuels [2][3] et les publications [4][5][6][7]. L'autorisation de la Commission fédérale d'experts du secret professionnel en matière de recherche médicale peut être consultée sur le site web du RSCE (www.kinderkrebsregister.ch), le site web de la Société suisse de pédiatrie (www.swiss-paediatrics.org) et le site web du GOPS (www.spog.ch).…”

Section: Informations Complémentaires Et Matériels Pour L'informationunclassified

Le Registre Suisse du Cancer de l'Enfant: premier registre du cancer national

2008

Bull Med Suisses

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Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age- and sex-related differences

Cited by 142 publications

References 21 publications

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Safety and tolerability of high doses of glucocorticoides

Le Registre Suisse du Cancer de l'Enfant: premier registre du cancer national

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