The evolutionary definition of intelligence has made it a multifaceted concept. Emo-sensory intelligence (ESQ), as integration of emotional intelligence (EQ) and sensory intelligence (SQ) is the sensitivity to the emotions evoked by sensory inputs. It puts emphasis on individuals’ ability to recognize, label, monitor, and manage sense-induced emotions to guide one’s behavior and establish emo-sensory communication. Among the studies done on different types of intelligence and effective communication, gender differences have been a recurring theme. The purpose of this study was to investigate the role of gender in emo-sensory intelligence and emo-sensory communication. To this aim, the emo-sensory intelligence scale (ESIS) was distributed to 1500 participants. The results revealed significant differences between the two genders in ESQ for visual, olfactory, and tactile senses, demonstrating the superiority of females over males. Moreover, a significant difference was found between the two genders in their ability to identify the basic emotions triggered by their senses, and use them in their communications, with females being better than males.