Intelligent Biomaterialomics: Molecular Design, Manufacturing, and Biomedical Applications

Abstract

Materialomics integrates experiment, theory, and computation in a high‐throughput manner, and has changed the paradigm for the research and development of new functional materials. Recently, with the rapid development of high‐throughput characterization and machine‐learning technologies, the establishment of biomaterialomics that tackles complex physiological behaviors has become accessible. Breakthroughs in the clinical translation of nanoparticle‐based therapeutics and vaccines have been observed. Herein, recent advances in biomaterials, including polymers, lipid‐like materials, and peptides/proteins, discovered through high‐throughput screening or machine learning‐assisted methods, are summarized. The molecular design of structure‐diversified libraries; high‐throughput characterization, screening, and preparation; and, their applications in drug delivery and clinical translation are discussed in detail. Furthermore, the prospects and main challenges in future biomaterialomics and high‐throughput screening development are highlighted.This article is protected by copyright. All rights reserved

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

“…(2) Enhancing the specificity and efficacy of regulators targeting Trx system protein activity or expression: The current regulators for Trx and its associated proteins exhibit limited specificity and selectivity. Employing advanced techniques such as computer-aided drug design, high-throughput screening, nanomedicine, and other innovative approaches holds great promise in developing highly effective regulators specifically targeting Trx and its related proteins [ [399] , [400] , [401] ]. (3) The intricate interplay and cross-talk mechanisms of multiple antioxidant systems in the process of aging and age-related diseases should not be solely attributed to Trx as the exclusive redox regulator within cells or tissues.…”

Self-assembly of peptide nanomaterials at biointerfaces: molecular design and biomedical applications

“…22–25 Self-assembled peptide nanomaterials possess unique characteristics, including multivalent surface properties, controllable phase transitions, and adjustable mechanical motion. 26,27 As a result, peptide assemblies exhibit greater stability, distinctive mechanical properties, and a wider range of biological activities compared to their monomeric counterparts. 28–30 “ In vivo self-assembly” is a new technique firstly proposed for constructing nanomaterials in situ within living organisms in 2015.…”

Enzyme-Induced Shape-Shifting Peptide Nanocarrier Coloaded with Paclitaxel and Dipyridamole Inhibits Platelet Function and Tumor Metastasis

“…The TME is a complex and variable region characterized by hypoxia, low pH, and the overexpression of enzymes. Some features of the TME provide conditions suitable for precise tumor-targeting therapies. − A high level of alkaline phosphatase (ALP) is an important marker of metastasis and poor healing in breast cancer . Utilizing ALP to induce structural changes in peptide nanocarriers offers a promising approach to enhancing the duration of chemotherapeutic agent retention at the tumor location …”