In wireless communication, multiple signals are utilized to receive and send information in the form of signals simultaneously. These signals consume little power and are usually inexpensive, with a high data rate during data transmission. An Multi Input Multi Output (MIMO) system uses numerous antennas to enhance the functionality of the system. Moreover, system intricacy and power utilization are difficult and highly complicated tasks to achieve in an Analog to Digital Converter (ADC) at the receiver side. An infinite number of MIMO channels are used in wireless networks to improve efficiency with Cross Entropy Optimization (CEO). ADC is a serious issue because the data of the accepted signal are completely lost. ADC is used in the MIMO channels to overcome the above issues, but it is very hard to implement and design. So, an efficient way to enhance the estimation of channels in the MIMO system is proposed in this paper with the utilization of the heuristic-based optimization technique. The main task of the implemented channel prediction framework is to predict the channel coefficient of the MIMO system at the transmitter side based on the receiver side error ratio, which is obtained from feedback information using a Hybrid Serial Cascaded Network (HSCN). Then, this multi-scaled cascaded autoencoder is combined with Long Short Term Memory (LSTM) with an attention mechanism. The parameters in the developed Hybrid Serial Cascaded Multi-scale Autoencoder and Attention LSTM are optimized using the developed Hybrid Revised Position-based Wild Horse and Energy Valley Optimizer (RP-WHEVO) algorithm for minimizing the “Root Mean Square Error (RMSE), Bit Error Rate (BER) and Mean Square Error (MSE)” of the estimated channel. Various experiments were carried out to analyze the accomplishment of the developed MIMO model. It was visible from the tests that the developed model enhanced the convergence rate and prediction performance along with a reduction in the computational costs.