The control of an ultra-supercritical (USC) boiler–turbine power plant is critical in maintaining the safety of the sustainable power grid. However, it is challenging due to the internal nonlinearity, hard manipulation constraints, and widespread uncertainties. To this end, a fuzzy extended state observer (FESO)-based stable fuzzy predictive control (SFPC) approach is developed in this paper. First, the control difficulties of the USC boiler–turbine unit are analyzed. Then, based on a Takagi–Sugeno (T–S) fuzzy model, a new FESO is developed for nonlinear systems to achieve a more precise observation performance. The gain of FESO is determined by solving a series of linear matrix inequalities, while guaranteeing the stability of FESO. Then, by combining the proposed FESO with the SFPC, an integrated FESO–SFPC algorithm is devised. The disturbance rejection ability of the FESO–SFPC algorithm is analyzed theoretically. Simulation results on a 1000 MW USC boiler–turbine power plant model further validate the effectiveness of the proposed method.