Intelligent Electrospinning Nanofibrous Membranes for Monitoring and Promotion of Wound Healing

Qu, Zhi; Wang, Yang; Dong, Yanhong; Li, Xinmeng; Hao, Lingwan; Sun, Liwei; Zhou, Lu; Jiang, Rujian; Liu, Weihua

doi:10.1016/j.mtbio.2024.101093

Cited by 4 publications

(2 citation statements)

References 154 publications

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“…Diabetic wound management remains a significant clinical challenge due to the complexity of wound healing in diabetic patients. 16 For example, the pH value of the diabetic wound varies depending on factors such as the severity of the wound and the presence of any infection. Specifically, the surface of healthy skin is weakly acidic, 17 supporting the skin's inherent ability to resist microbial invasion.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Janus Membrane for Diabetic Wound Healing and Intelligent Monitoring

Liu,

Xi,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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The complex microenvironment of diabetic wounds often hinders the healing process, ultimately leading to the formation of diabetic foot ulcers and even death. Dual monitoring and treatment of wounds can significantly reduce the incidence of such cases. Herein, a multifunctional Janus membrane (3D chitosan sponge-ZE/polycaprolactone nanofibers-ZP) was developed by incorporating the zinc metal−organic framework, europium metal−organic framework, and phenol red into nanofibers for diabetic wound monitoring and treatment. The directional water transport capacity of the resulting Janus membrane allows for unidirectional and irreversible drainage of wound exudate, and the multifunctional Janus membrane creates up to a 99% antibacterial environment, both of which can treat wounds. Moreover, the pH (5−8) and H 2 O 2 (0.00−0.80 μM) levels of the wound can be monitored using the color-changing property of phenol red and the fluorescence characteristic of Eu-MOF on the obtained membrane, respectively. The healing stages of the wound can also be monitored by analyzing the RGB values of the targeted membrane images. This design can more accurately reflect the wound state and treat the wound to reduce bacterial infection and accelerate wound healing, which has been demonstrated in in vivo experiments. The results provide an important basis for early intervention in diabetic patients.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Diabetic wound management remains a significant clinical challenge due to the complexity of wound healing in diabetic patients . For example, the pH value of the diabetic wound varies depending on factors such as the severity of the wound and the presence of any infection.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Janus Membrane for Diabetic Wound Healing and Intelligent Monitoring

Liu,

Xi,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Negative Pressure Smart Patch to Sense and Heal the Wound

Liu,

Zhao,

et al. 2024

Advanced Science

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Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub‐vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information about the real status of the wound bed and the potential risk of infection. To address this concern, printed Negative Pressure Smart Patch (NPSP) is reported by integrating smart real‐time sensing acidity (infection) and glucose, and anti‐infection into NPWT systems. In addition, NPSP delivers vancomycin through chitosan porous microspheres under negative pressure to modulate wound healing. Compared with NPWT, NPSP projects a promising approach to removing bacteria, reducing local inflammation, and accelerating healing in a short period of time.

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Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review

Astaneh,

Fereydouni

2024

International Journal of Polymeric Materials and Polymeric Biom

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Intelligent Electrospinning Nanofibrous Membranes for Monitoring and Promotion of Wound Healing

Cited by 4 publications

References 154 publications

Multifunctional Janus Membrane for Diabetic Wound Healing and Intelligent Monitoring

Multifunctional Janus Membrane for Diabetic Wound Healing and Intelligent Monitoring

Negative Pressure Smart Patch to Sense and Heal the Wound

Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review

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