“Intelligent” Fingerprinting: Simultaneous Identification of Drug Metabolites and Individuals by Using Antibody‐Functionalized Nanoparticles

Leggett, Richard M.; Lee-Smith, E; Jickells, Sue M.; Russell, David A.

doi:10.1002/ange.200700217

Cited by 66 publications

(61 citation statements)

References 13 publications

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“…b [23] (http://www.whitehousedrugpolicy.gov/publications/pdf/prescrip_disposal.pdf). Sweat contributes to two pathways for transporting APIs to the immediate and surrounding environments: direct exposure of others and contamination of surrounding objects via dermal contact (e.g., drugs released in sweat through the rows of pores located along fingerprint ridges are known to be deposited in fingerprints) [34] and release of APIs directly to sewers, via bathing and other hygiene activities.…”

Section: Sweat As a Route Of Excretionmentioning

confidence: 99%

Environmental footprint of pharmaceuticals: The significance of factors beyond direct excretion to sewers

Daughton¹,

Ruhoy²

2009

Enviro Toxic and Chemistry

200

113

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Abstract-The combined excretion of active pharmaceutical ingredients (APIs) via urine and feces is considered the primary route by which APIs from human pharmaceuticals enter the environment. Disposal of unwanted, leftover medications by flushing into sewers has been considered a secondary route-one that does not contribute substantially to overall environmental loadings. The present study presents the first comprehensive examination of secondary routes of API release to the environment and for direct but unintentional human exposure. These include bathing, washing, and laundering, all of which release APIs remaining on the skin from the use of high-content dermal applications or from excretion to the skin via sweating, and disposal of unused and partially used highcontent devices. Also discussed are the health hazards associated with: partially used devices, medication disposal practices of consumers, and interpersonal dermal transfer of API residues. Understanding these secondary routes is important from the perspective of pollution prevention, because actions can be designed more easily for reducing the environmental impact of APIs compared with the route of direct excretion (via urine and feces), for reducing the incidence of unintentional and purposeful poisonings of humans and pets, and for improving the quality and cost-effectiveness of health care. Overall, unintentional exposure to APIs for humans via these routes is possibly more important than exposure to trace residues recycled from the environment in drinking water or foods.

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Section: Sweat As a Route Of Excretionmentioning

confidence: 99%

Environmental footprint of pharmaceuticals: The significance of factors beyond direct excretion to sewers

Daughton¹,

Ruhoy²

2009

Enviro Toxic and Chemistry

200

113

View full text Add to dashboard Cite

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“…The field of fingerprint chemical analysis is also a rapidly growing research area, starting from a recent paradigm shift in the forensic community for using fingerprints for more than just their ridge detail [21][22][23][24][25][26][27][28][29]. It has been previously shown that the chemical composition relates to the age of a latent fingerprint [28], the sex of the donor [24], their drug habits or medical history [17][18][19][20], the way they interact with development reagents [21] and might even be used to confirm their identity using their amino acid profile [29] or to verify their location on questioned documents [23]. This may be useful when a fingerprint is smudged or details of the donor are not contained within the fingerprint database.…”

Section: Introductionmentioning

confidence: 99%

Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS – opportunities for forensic and biomedical science

et al. 2016

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Liquid Extraction Surface Analysis (LESA) is a new, high throughput tool for ambient mass spectrometry. A solvent droplet is deposited from a pipette tip onto a surface and maintains contact with both the surface and the pipette tip for a few seconds before being re-aspirated. The technique is particularly suited to the analysis of trace materials on surfaces due to its high sensitivity and low volume of sample removal. In this work, we assess the suitability of LESA for obtaining detailed chemical profiles of fingerprints, oral fluid and urine, which may be used in future for rapid medical diagnostics or metabolomics studies. We further show how LESA can be used to detect illicit drugs and their metabolites in urine, oral fluid and fingerprints. This makes LESA a potentially useful tool in the growing field of fingerprint chemical analysis, which is relevant not only to forensics but also to medical diagnostics. Finally, we show how LESA can be used to detect the explosive material RDX in contaminated artificial fingermarks.

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“…This provides the ability to tune the solubility in different solvents, but also and especially to tailor the affinity with papillary secretion compounds. For example, the molecular grafting -also called functionalization -has already led to the detection of metabolites in secretions [13][14][15][16]. In Leggett's work [13], gold nanoparticles were functionalized with antibodies targeting the cotinine (i.e., the metabolite of nicotine), that can be found in the sweat of smokers.…”

mentioning

confidence: 99%

Cadmium-free quantum dots in aqueous solution: Potential for fingermark detection, synthesis and an application to the detection of fingermarks in blood on non-porous surfaces

Moret

Bécue

Champod

2013

Forensic Science International

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The use of quantum dots (QDs) in the area of fingermark detection is currently receiving a lot of attention in the forensic literature. Most of the research efforts have been devoted to cadmium telluride (CdTe) quantum dots often applied as powders to the surfaces of interests.Both the use of cadmium and the nano size of these particles raise important issues in terms of health and safety. This paper proposes to replace CdTe QDs by zinc sulphide QDs doped with copper (ZnS:Cu) to address these issues. Zinc sulphide-copper doped QDs were successfully synthesized, characterized in terms of size and optical properties and optimized to be applied for the detection of impressions left in blood, where CdTe QDs proved to be efficient. Effectiveness of detection was assessed in comparison with CdTe QDs and Acid Yellow 7(AY7, an effective blood reagent), using two series of depletive blood fingermarks from four donors prepared on four non-porous substrates, i.e. glass, transparent polypropylene, black polyethylene and aluminium foil. The marks were cut in half and processed separately with both reagents, leading to two comparison series (ZnS:Cu vs. CdTe, and ZnS:Cu vs. AY7).ZnS:Cu proved to be better than AY7 and at least as efficient as CdTe on most substrates.Consequently, copper-doped ZnS QDs constitute a valid substitute for cadmium-based QDs to detect blood marks on non-porous substrates and offer a safer alternative for routine use.

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“Intelligent” Fingerprinting: Simultaneous Identification of Drug Metabolites and Individuals by Using Antibody‐Functionalized Nanoparticles

Cited by 66 publications

References 13 publications

Environmental footprint of pharmaceuticals: The significance of factors beyond direct excretion to sewers

Environmental footprint of pharmaceuticals: The significance of factors beyond direct excretion to sewers

Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS – opportunities for forensic and biomedical science

Cadmium-free quantum dots in aqueous solution: Potential for fingermark detection, synthesis and an application to the detection of fingermarks in blood on non-porous surfaces

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