Intelligent Multi-Electrode Arrays as the Next Generation of Electrochemical Biosensors for Real-Time Analysis of Neurotransmitters

Mazafi, Alon; Shukla, Rajendra P.; Shukla, Sudheesh K.; Lavon, Avia; Ben‐Yoav, Hadar; Silue, Adissa; McDowell, Ben; Peixoto, Nathalia

doi:10.1109/memea.2018.8438720

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…A multielectrode array was suggested for the voltammetric quantification of neurotransmitters dopamine and norepinephrine in biological fluids in situ, i.e., without any pretreatment steps [ 65 ]. The electrodes were modified with chitosan and carbon nanotubes, and the data were used to build a PLS regression model with RMSEP < 3 µM for both of the studied neurotransmitters in the concentration range 1–25 µM.…”

Section: Application Of Chemometrics In Different Fields Of Biosenmentioning

confidence: 99%

Application of Chemometrics in Biosensing: A Brief Review

Martynko

Kirsanov

2020

Biosensors

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The field of biosensing is rapidly developing, and the number of novel sensor architectures and different sensing elements is growing fast. One of the most important features of all biosensors is their very high selectivity stemming from the use of bioreceptor recognition elements. The typical calibration of a biosensor requires simple univariate regression to relate a response value with an analyte concentration. Nevertheless, dealing with complex real-world sample matrices may sometimes lead to undesired interference effects from various components. This is where chemometric tools can do a good job in extracting relevant information, improving selectivity, circumventing a non-linearity in a response. This brief review aims to discuss the motivation for the application of chemometric tools in biosensing and provide some examples of such applications from the recent literature.

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Section: Application Of Chemometrics In Different Fields Of Biosenmentioning

confidence: 99%