Intelligent Nanoarchitectonics for Self‐Assembling Systems

Ariga, Katsuhiko

doi:10.1002/aisy.201900157

Cited by 15 publications

(12 citation statements)

References 235 publications

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“…The cysteine residue plays a pivotal role in protecting the body from oxidation damage; however, GSH is easily metabolized by enzymes [23]. In this work, we employed a facile co-assembly strategy to design hybrid nanoparticles as antioxidants [24][25][26][27][28][29][30][31]. Myr, Zn 2+ , and GSH were co-assembled to Myr-Zn 2+ -GSH (MZG) nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Ma¹,

Gong²,

Ogino³

et al. 2022

Beilstein J. Nanotechnol.

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Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of antioxidative reagents is an important strategy to alleviate chronic diseases and maintain the redox balance in cells. Small-molecule bioactive compounds have exhibited huge therapeutic potential as antioxidants and anti-inﬂammatory agents. Myricetin (Myr), a well-known natural flavonoid, has drawn wide attention because of its high antioxidant, anti-inflammatory, antimicrobial, and anticancer efficacy. Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. However, Myr is poorly soluble in water, which limits its bioavailability for biomedical applications, and even its clinical therapeutic potential. The antioxidant peptide glutathione (GSH) plays a role as antioxidant in cells and possesses good hydrophilicity and biocompatibility. However, it is easily metabolized by enzymes. To take advantages of their antioxidation activity and to overcome the abovementioned limitations, GSH, Zn2+, and Myr were selected to co-assemble into Myr-Zn2+-GSH nanoparticles or nanoarchitectonics. This study oﬀers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity, high bioavailability, and good biocompatibility as antioxidants.

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Section: Introductionmentioning

confidence: 99%

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Ma¹,

Gong²,

Ogino³

et al. 2022

Beilstein J. Nanotechnol.

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“…Thus, implementing this concept by combining tools from research fields including nanotechnology, (bio)material science, and organic and polymer chemistry has ensured that considerable advances have been made in the elaboration of dynamic materials and systems relying on reversible non-covalent interactions [ 3 ]. Typically, the reversible nature of interactions with and within functional nano-units provides materials with self-assembly synthesis routes, structural control, encapsulation abilities, and responses to stimuli [ 4 ]. In this context, polyelectrolytes occupy a central position in many nanoarchitectured systems owing to their multipotent properties, enabling them to act as reticulation/bridging agents, stabilizers, structure directors, and matrix components in functional coatings, gels, and colloidal systems [ 4 , 5 ].…”

Section: Contextmentioning

confidence: 99%

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

et al. 2022

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The ionization degree, charge density, and conformation of weak polyelectrolytes can be adjusted through adjusting the pH and ionic strength stimuli. Such polymers thus offer a range of reversible interactions, including electrostatic complexation, H-bonding, and hydrophobic interactions, which position weak polyelectrolytes as key nano-units for the design of dynamic systems with precise structures, compositions, and responses to stimuli. The purpose of this review article is to discuss recent examples of nanoarchitectonic systems and applications that use weak polyelectrolytes as smart components. Surface platforms (electrodeposited films, brushes), multilayers (coatings and capsules), processed polyelectrolyte complexes (gels and membranes), and pharmaceutical vectors from both synthetic or natural-type weak polyelectrolytes are discussed. Finally, the increasing significance of block copolymers with weak polyion blocks is discussed with respect to the design of nanovectors by micellization and film/membrane nanopatterning via phase separation.

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“…The nanoarchitectonics approaches have strong bio-similar features, and constructions of bio-like high functional systems would be one of the ultimate goals [ 233 , 234 ]. Sophisticated functions and structures in biological systems are the result of evolutionary processes over billions of years, but nanoarchitectonics have to be complete their task within a few decades [ 235 ]. Newly developed technologies such as machine learning and artificial intelligence [ 236 , 237 , 238 , 239 ] could assist the rapid evolution of molecular and materials nanoarchitectonics approaches.…”

Section: Perspectivesmentioning

confidence: 99%

Progress in Molecular Nanoarchitectonics and Materials Nanoarchitectonics

Ariga

2021

Molecules

Self Cite

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Although various synthetic methodologies including organic synthesis, polymer chemistry, and materials science are the main contributors to the production of functional materials, the importance of regulation of nanoscale structures for better performance has become clear with recent science and technology developments. Therefore, a new research paradigm to produce functional material systems from nanoscale units has to be created as an advancement of nanoscale science. This task is assigned to an emerging concept, nanoarchitectonics, which aims to produce functional materials and functional structures from nanoscale unit components. This can be done through combining nanotechnology with the other research fields such as organic chemistry, supramolecular chemistry, materials science, and bio-related science. In this review article, the basic-level of nanoarchitectonics is first presented with atom/molecular-level structure formations and conversions from molecular units to functional materials. Then, two typical application-oriented nanoarchitectonics efforts in energy-oriented applications and bio-related applications are discussed. Finally, future directions of the molecular and materials nanoarchitectonics concepts for advancement of functional nanomaterials are briefly discussed.

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Intelligent Nanoarchitectonics for Self‐Assembling Systems

Cited by 15 publications

References 235 publications

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

Progress in Molecular Nanoarchitectonics and Materials Nanoarchitectonics

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