Intelligent Numerical Manipulation of Micrometer-Scale Emulsions Using Polymer Confinement

Abstract

The manipulation of emulsions at micrometer-scale is a challenging topic for industrial application, especially for monodisperse microemulsions production. The development of material science and afterwards the creation of polymer confinement proposed efficient devices for micrometer scale emulsions fabrication. In this work, the flow regime of emulsion generation was studied to depict numerical manipulation of micrometer-scale emulsions through biomicrofluidic technology. At first, correlation analysis between experiment conditions and results were conducted, then different linear modeling and non-linear modeling, including Artificial Neural Network Modeling (NNM) technology, were performed to characterize the emulsion variation. Both models can well manipulate emulsion variation. Compared with linear modeling, non-linear models ameliorate the performance on the manipulation of micrometer-scale emulsion.

Analytical Modeling and Numerical Simulations on the Scaling of Biomicrofluidic Droplets

“…Concentration gradient was created in the microfluidic channels to analyze single bacterial chemotaxis or to analyze single cell dynamic phenomenon in microdroplets [7,8]. Especially, droplet-based system as a typical representation in biomicrfluidics has attracted wide interests from the scientific advances to the industrial evolutions since over ten years ago [9][10][11][12]. Delicate biomicrofluidic systems allowed for the generation of biocompatible microdroplets.…”