Intelligent photothermal dendritic cells restart the cancer immunity cycle through enhanced immunogenic cell death

Sun, Zhihong; Deng, Guanjun; Peng, Xinghua; Xu, Xiuli; Liu, Lanlan; Peng, Jiaofeng; Ma, Yifan; Zhang, Pengfei; Wen, Austin; Wang, Yifan; Yang, Zhaogang; Gong, Ping; Jiang, Wen; Cai, Lintao

doi:10.1016/j.biomaterials.2021.121228

Cited by 55 publications

(61 citation statements)

References 73 publications

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“…The inclusion of immunostimulants and/or ICIs in the nanomaterials’ phototherapies is crucial to further boost the therapeutic outcome [ 37 , 65 , 71 , 75 , 106 ]. For instance, Ou and co-workers prepared PEGylated Glucocorticoid-induced Cancer Necrosis Factor Receptor (GITR)-functionalized PLGA nanoparticles incorporating IR780 and Imatinib (diminishes immunosuppression mediated by T reg cells [ 123 ]) for application in cancer immuno-PTT/PDT [ 71 ].…”

Section: Prototypic Hc-loaded Nanomaterials In Cancer Immuno-ptt/pdtmentioning

confidence: 99%

“…Among the different NIR light-responsive nanomaterials (e.g., graphene derivatives [ 57 , 58 ], gold nanorods [ 59 , 60 ]), those incorporating heptamethine cyanines (HCs) have received great interest [ 61 , 62 , 63 , 64 , 65 , 66 ]. These nanostructures can be simply prepared by loading the HCs into the hydrophobic reservoirs of the nanomaterials [ 61 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

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Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

et al. 2022

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The development of strategies capable of eliminating metastasized cancer cells and preventing tumor recurrence is an exciting and extremely important area of research. In this regard, therapeutic approaches that explore the synergies between nanomaterial-mediated phototherapies and immunostimulants/immune checkpoint inhibitors have been yielding remarkable results in pre-clinical cancer models. These nanomaterials can accumulate in tumors and trigger, after irradiation of the primary tumor with near infrared light, a localized temperature increase and/or reactive oxygen species. These effects caused damage in cancer cells at the primary site and can also (i) relieve tumor hypoxia, (ii) release tumor-associated antigens and danger-associated molecular patterns, and (iii) induced a pro-inflammatory response. Such events will then synergize with the activity of immunostimulants and immune checkpoint inhibitors, paving the way for strong T cell responses against metastasized cancer cells and the creation of immune memory. Among the different nanomaterials aimed for cancer immuno-phototherapy, those incorporating near infrared-absorbing heptamethine cyanines (Indocyanine Green, IR775, IR780, IR797, IR820) have been showing promising results due to their multifunctionality, safety, and straightforward formulation. In this review, combined approaches based on phototherapies mediated by heptamethine cyanine-loaded nanomaterials and immunostimulants/immune checkpoint inhibitor actions are analyzed, focusing on their ability to modulate the action of the different immune system cells, eliminate metastasized cancer cells, and prevent tumor recurrence.

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Section: Prototypic Hc-loaded Nanomaterials In Cancer Immuno-ptt/pdtmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

et al. 2022

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“…T cell activation induced by DCs membrane combined with PTT could make tumors susceptible to heat stress by reducing heat shock protein (HSP) expression (Figure 4B). 72 Stem Cells Membrane. Various types of stem cells, including bone marrow mesenchymal stem cells (MSCs) and neural stem cells (NSCs), can be isolated and cultured in vitro for a long time.…”

Section: ■ Cells Membrane Coatingmentioning

confidence: 99%

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

Wang

et al. 2022

ACS Materials Lett.

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Antitumor nanoparticles now confront several obstacles, including poor biocompatibility and biodegradability, quick removal, and a short cycle time, given the growing interest in surface membrane coating as a versatile platform for altering nanoparticles and overcoming the limitations of current nanodrug delivery methods. This paper reviews the recent progress of cells, synthetic polymers, polyphenols, and polysaccharides membrane coatings with favorable biocompatibility and biodegradability and easy surface modification on the surface of antitumor nanoparticle platforms, which can provide a promising strategy for endowing nanoparticles with specific and expected performance to optimize the efficiency of antitumor. Furthermore, multiple membrane combination strategies and additional biorecognition ligands modification on the membrane surface are supplied in an attempt to tackle the challenges of single membrane coating in a variety of tumor therapeutic applications and ultimately facilitate effective clinical transformation.

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“…Dendritic cells (DCs) are major antigen presenting cells (APCs) and play important roles in activating and priming CD4 + or CD8 + T cells to shape adaptive immunity. [13][14][15][16] Under immune activation conditions, DCs undergo maturation and upregulate their antigen presentation function to initiate antigen-specific immune responses. [17][18][19] It has been reported that the engagement of the insulin receptor and IGF-1 receptor can induce APC maturation.…”

Section: Biomaterials Sciencementioning

confidence: 99%

Amino acid sequence determines the adjuvant potency of ad-tetra-peptide hydrogel

Zhang

et al. 2022

Biomater. Sci.

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Intelligent photothermal dendritic cells restart the cancer immunity cycle through enhanced immunogenic cell death

Cited by 55 publications

References 73 publications

Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

Amino acid sequence determines the adjuvant potency of ad-tetra-peptide hydrogel

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