Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery

Kim, Il; Lu, Yiming; Xu, Yixin; Yu, Deng‐Guang; Song, Wenliang

doi:10.1016/j.jconrel.2022.08.005

Cited by 52 publications

(36 citation statements)

References 229 publications

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“…It can be concluded that with the increase in the content of antibacterial active substances, the antibacterial activity of the fiber membrane packaging increased correspondingly, indicating that nanosilver and resveratrol had a synergistic effect on their antibacterial activity. Along this proof-of-concept demonstration and with the capability of electrospinning in creating complex nanostructures such as Janus particles, a tri-layer core-sheath and their combinations [ 95 , 96 , 97 ], many novel fiber membranes loaded with multiple active ingredients will be further developed for food packaging in the future, particularly from many bioactive molecules [ 98 , 99 ].…”

Section: Resultsmentioning

confidence: 99%

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

et al. 2022

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The purpose of this work is to develop a novel ultrathin fibrous membrane with a core-sheath structure as antibacterial food packaging film. Coaxial electrospinning was exploited to create the core-sheath structure, by which the delivery regulation of the active substance was achieved. Resveratrol (RE) and silver nanoparticles (AgNPs) were loaded into electrospun zein/polyethylene oxide ultrathin fibers to ensure a synergistic antibacterial performance. Under the assessments of a scanning electron microscope and transmission electron microscope, the ultrathin fiber was demonstrated to have a fine linear morphology, smooth surface and obvious core-sheath structure. X-ray diffraction and Fourier transform infrared analyses showed that RE and AgNPs coexisted in the ultrathin fibers and had good compatibility with the polymeric matrices. The water contact angle experiments were conducted to evaluate the hydrophilicity and hygroscopicity of the fibers. In vitro dissolution tests revealed that RE was released in a sustained manner. In the antibacterial experiments against Staphylococcus aureus and Escherichia coli, the diameters of the inhibition zone of the fiber were 8.89 ± 0.09 mm and 7.26 ± 0.10 mm, respectively. Finally, cherry tomatoes were selected as the packaging object and packed with fiber films. In a practical application, the fiber films effectively reduced the bacteria and decreased the quality loss of cherry tomatoes, thereby prolonging the fresh-keeping period of cherry tomatoes to 12 days. Following the protocols reported here, many new food packaging films can be similarly developed in the future.

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Section: Resultsmentioning

confidence: 99%

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

et al. 2022

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“…We conclude that dual stimuli such as pH and temperature resulted in the highest efficiency of Cur release from the PNIPAm-co-PAAm@Cur HG system, as compared to the individual stimuli (either pH or temperature). Several types of doping materials have been employed in the literature ( Table 1 and Table 2 ) for the loading/release of various drugs, including Cur; however, thermoresponsive PNIPAm-based polymers have advantages, such as the capability to release drugs under physiological and external temperature stimulation circumstances [ 36 , 37 , 38 , 39 , 40 ]. The majority of the studies on thermoresponsive copolymers described in the literature [ 41 , 42 , 43 , 44 ] have focused on thermoresponsive behavior; however, the suggested PNIPAm-co-PAAm HG system functions as a dual pH and temperature-responsive cur-cumin delivery system.…”

Section: Resultsmentioning

confidence: 99%

Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery

et al. 2022

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Stimuli-response polymeric nanoparticles have emerged as a carrier system for various types of therapeutic delivery. In this study, we prepared a dual pH- and thermo-sensitive copolymer hydrogel (HG) system (PNIPAm-co-PAAm HG), using N-isopropyl acrylamide (NIPAm) and acrylamide (AAm) as comonomers. The synthesized PNIPAm-co-PAAm HG was characterized using various instrumental characterizations. Moreover, the PNIPAm-co-PAAm HG’s thermoresponsive phase transition behavior was investigated, and the results showed that the prepared HG responds to temperature changes. In vitro drug loading and release behavior of PNIPAm-co-PAAm HG was investigated using Curcumin (Cur) as the model cargo under different pH and temperature conditions. The PNIPAm-co-PAAm HG showed pH and temperature-responsive drug release behavior and demonstrated about 65% Cur loading efficiency. A nearly complete release of the loaded Cur occurred from the PNIPAm-co-PAAm HG over 4 h at pH 5.5 and 40 °C. The cytotoxicity study was performed on a liver cancer cell line (HepG2 cells), which revealed that the prepared PNIPAm-co-PAAm HG showed good biocompatibility, suggesting that it could be applied as a drug delivery carrier. Moreover, the in vitro cytocompatibility test (MTT assay) results revealed that the PNIPAm-co-PAAm HG is biocompatible. Therefore, the PNIPAm-co-PAAm HG has the potential to be useful in the delivery of drugs in solid tumor-targeted therapy.

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“…Apart from GNCs, there are several nanomaterials which have been reported for nanomedicine. Among the reported carbon, Au, Fe, Si, dendrimer, and polymer nanomaterials are highly suitable as novel theranostic agents [ 160 , 161 , 162 , 163 , 164 ]. Graphene has a great advantage over other nanomaterials due its tunable size, dimensionality, tunable surface, covalent and non-covalent chemistry, atomic sensitivity and <nm thickness, easy synthesis, and its economic availability for both cancer therapy and antibacterial activity [ 165 , 166 , 167 ].…”

Section: Graphene Nanocomposite Theranostics For Multimodal Imaging G...mentioning

confidence: 99%

Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites

2022

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The advancements in nanotechnology and nanomedicine are projected to solve many glitches in medicine, especially in the fields of cancer and infectious diseases, which are ranked in the top five most dangerous deadly diseases worldwide by the WHO. There is great concern to eradicate these problems with accurate diagnosis and therapies. Among many developed therapeutic models, near infra-red mediated phototherapy is a non-invasive technique used to invade many persistent tumors and bacterial infections with less inflammation compared with traditional therapeutic models such as radiation therapy, chemotherapy, and surgeries. Herein, we firstly summarize the up-to-date research on graphene phototheranostics for a better understanding of this field of research. We discuss the preparation and functionalization of graphene nanomaterials with various biocompatible components, such as metals, metal oxides, polymers, photosensitizers, and drugs, through covalent and noncovalent approaches. The multifunctional nanographene is used to diagnose the disease with confocal laser scanning microscopy, magnetic resonance imaging computed tomography, positron emission tomography, photoacoustic imaging, Raman, and ToF-SMIS to visualize inside the biological system for imaging-guided therapy are discussed. Further, treatment of disease by photothermal and photodynamic therapies against different cancers and bacterial infections are carefully conferred herein along with challenges and future perspectives.

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Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery

Cited by 52 publications

References 229 publications

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery

Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites

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