Burnout is a state of exhaustion that results from prolonged, excessive workplace stress. This can be examined with the biological explications of burnout and physical consequences and classified against prolonged vigorous activities. The research aims to classify burnout people's brain images against prolonged emotional activities using ontology analysis of treatment and prevention and intermediate layers formation based on a speculative sense model. In this segment, the Ontology analysis of Treatment and prevention and intermediate layers formation based on a hypothetical sense model is employed for burnout people's classification analysis. The methodology is performed in the platform of ontology creation and performs the classification analysis. The calculation analysis found the result, and the brain images were classified. The classification analysis of burnout people's brain images, separation of prolonged vigorous activities, and the ontology creation for treatment and prevention against burnout people's brain images were obtained. The analysis received the result, and the results of the precision, recall, storage, computation time, specificity, and classification of burnout people's brain images were obtained. Furthermore, all these Ontology analysis of Treatment and prevention and intermediate layers formation based on a hypothetical sense model had the prediction sensitivity (SN) over 50% and specificity (SP) over 90%. The Classification of Burnout People's Brain performance comparison shows that the proposed system is much more successful than existing methods, especially on a scoring accuracy of 98%.