Intelligent sensing based on active micro/nanomotors

Jiang, Linfeng; Liu, Xiaoxia; Zhao, Dongfang; Guo, Jinhong; Ma, Xiaoxuan; Wang, Yong

doi:10.1039/d3tb01163a

Cited by 5 publications

(3 citation statements)

References 126 publications

(151 reference statements)

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“…In addition, for cancer diagnosis, micro-mixing, along with the enhanced mass transfer produced by micromotor propulsion, has been utilized to enhance biosensing efficiency [ 139 , 151 , 152 , 153 ]. Still, nano/micromotors with different motion behaviors (microswarm versus individuals) have not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Zheng,

Huang,

Lin

et al. 2023

Pharmaceutics

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Nano/micromotors are artificial robots at the nano/microscale that are capable of transforming energy into mechanical movement. In cancer diagnosis or therapy, such “tiny robots” show great promise for targeted drug delivery, cell removal/killing, and even related biomarker sensing. Yet biocompatibility is still the most critical challenge that restricts such techniques from transitioning from the laboratory to clinical applications. In this review, we emphasize the biocompatibility aspect of nano/micromotors to show the great efforts made by researchers to promote their clinical application, mainly including non-toxic fuel propulsion (inorganic catalysts, enzyme, etc.), bio-hybrid designs, ultrasound propulsion, light-triggered propulsion, magnetic propulsion, dual propulsion, and, in particular, the cooperative swarm-based strategy for increasing therapeutic effects. Future challenges in translating nano/micromotors into real applications and the potential directions for increasing biocompatibility are also described.

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Section: Discussionmentioning

confidence: 99%

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Zheng,

Huang,

Lin

et al. 2023

Pharmaceutics

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“…Micro/nanomotors are devices that can transform multiple types of energy into sufficient kinetic energy to overcome the viscous drag force of the fluid and the Brownian (random) motion with a wide range of potential applications, including environmental monitoring, [1][2][3] biosensors, [4][5][6] or drug delivery. [7][8][9] The reader is referred to a variety of reviews and progress reports on different aspects of motors.…”

Section: Introductionmentioning

confidence: 99%

Collagenase motors in gelatine-based hydrogels

Wang,

Floriano Marcelino,

Ade

et al. 2024

Nanoscale

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“…They can only qualitatively and semiquantitatively analyze key molecules involved in tumor development . The real-time interrelationship between these molecules and clinical information cannot be effectively displayed, making it challenging to accurately reveal the tumor progression process and comprehensively evaluate macroscopic tumor invasion behavior. , Moreover, these technologies require the extraction and processing of tumor cells or tissue specimens, losing the three-dimensional information on the primary tumor. Invasive detection methods may also lead to tumor metastasis.…”

Section: Introductionmentioning

confidence: 99%

A Clinically Feasible Diagnostic Electrochemical Micronano Motors Biosensor Built on Miniature Swimmer for Multiplex Detection and Grading of Breast Cancer Biomarkers

Zhang,

Liu,

et al. 2024

Anal. Chem.

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Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), and Ki67 are four crucial biomarkers used in the clinical diagnosis of breast cancer. Accurate detection of these biomarkers is essential for an effective diagnosis and treatment. MOF-based micronano motors (MOFtors) are promising for various applications, including environmental remediation, targeted nanosurgery, and biomarker detection. This paper presents a clinically feasible diagnostic electrochemical micronano motor biosensor, built on a miniature swimmer, for the multiplex detection and grading of breast cancer biomarkers. We designed a biosensor, named MOFtor-MSEM, incorporating aptamers and antibodies functionalized on SiO 2 @Co−Fe-MOF, which acts as a miniature swimmer in solution. The SiO 2 @Co−Fe-MOF serves as the body, while complementary double-chain-linked antibodies function as paddles. In a homogeneous solution, when a positive voltage is applied to the working electrode, the electrostatic interaction between the neutral SiO 2 @Co−Fe-MOF and the negatively charged complementary double-linked antibody causes the antibody to move toward the electrode and then regress due to water resistance. This back-and-forth motion propels the miniature swimmer, enabling it to move the target analyte through the solution. The sensor features an automatic "sample-amplifying signal-output" process, achieving simultaneous signal amplification and output of four electrochemical signals on a single nanomaterial, a significant challenge in electrochemical sensing. The biosensor boasts a short detection time of 40 min, compared to approximately 1 week for current clinical tissue testing. Additionally, the bioplatform selectively detects HER2, ER, Ki67, and PR in the range of 0−1500 pg/mL, with detection limits of 0.01420, 0.03201, 0.01430, and 0.01229 pg/mL, respectively.

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Intelligent sensing based on active micro/nanomotors

Abstract: In the microscopic world, synthetic micro/nanomotors (MNMs) can convert a variety of energy sources into driving forces to help humans perform a number of complex tasks with greater ease and...

Cited by 5 publications

References 126 publications

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Collagenase motors in gelatine-based hydrogels

A Clinically Feasible Diagnostic Electrochemical Micronano Motors Biosensor Built on Miniature Swimmer for Multiplex Detection and Grading of Breast Cancer Biomarkers

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