Intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD)–related dry eye disease (DED): a systematic review and meta-analysis

Lei, Yahui; Peng, Jing; Liu, Jiayan; Zhong, Jingxiang

doi:10.1007/s10103-022-03690-1

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…15,16 The treatment can have a lasting effect up to 9 months. 11,17,18 However, clinical trials studying the impact of IPL on MGD often exclude subjects using ocular hypotensive agents, leaving the effect of IPL on glaucoma eyes uncertain. 19,20,21,22,23 A non-comparative retrospective study analyzing the IPL effect in patients using ocular hypotensive agents reported short-term (4 weeks) results, revealing signi cant improvements in subjective symptoms, ocular surface staining, MG expressibility, tear osmolarity and tear meniscus height.…”

Section: Introductionmentioning

confidence: 99%

One-year outcome of intense pulsed light therapy for refractory meibomian gland dysfunction in patients continuously exposed to hypotensive agents: a comparative study

Fan,

Yang,

et al. 2023

Preprint

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Background: To compare the one-year effect of intense pulsed light (IPL) for refractory meibomian gland dysfunction (MGD) between patients treated with and without topical hypotensive agents. Methods: This comparative retrospective cohort study included 41 MGD eyes of glaucoma patients (age, 67.59±11.12 years) and 41 MGD eyes of non-glaucoma patients (age, 62.73±15.97 years). Both arms received a course of IPL with meibomian gland (MG) expression (MGX). Baseline characteristics were matched by propensity score test. Standard evaluation including eye dryness (SPEED) questionnaire, tear breakup time (TBUT), lid telangiectasia, corneal fluorescein staining (CFS) score, meibum quality and expressibility were assessed at baseline, 3, 6, 9 and 12 months after treatment. Results: No baseline intergroup heterogeneity was detected after matching. Both groups demonstrated significant improvements in SPEED score (-6.37 vs -3.23), lid telangiectasia (-0.62 vs -0.60), MG expressibility (-0.66 vs -0.93) and meibum quality (-0.83 vs -0.84) at 6 months (all p < 0.01), with a sustainable effect up to 9 months in glaucoma group and 12 months in non-glaucoma group in terms of SPEED score and MG expressibility. Both arms showed significant improvements in TBUT and meibum quality at 12 months (p < 0.01). CFS significantly decreased in the non-glaucoma group at 6 months while there was no significant change of CFS in glaucoma group over the follow-up period. Conclusions: IPL with regular MGX exerts a promising sustainable effect in ameliorating symptoms and signs of MGD patients treated with topical hypotensive agents, but the effect lasts shorter than that in non-glaucoma patients.

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Section: Introductionmentioning

confidence: 99%

One-year outcome of intense pulsed light therapy for refractory meibomian gland dysfunction in patients continuously exposed to hypotensive agents: a comparative study

Fan,

Yang,

et al. 2023

Preprint

View full text Add to dashboard Cite

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Nanosecond Pulse Generation in the C-Band Region Using Silver Sulfide as a Saturable Absorber

Ahmed,

Zulkipli,

Hassan

et al. 2024

J Russ Laser Res

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Long-Term Impacts of Intense Pulsed Light Therapy on Ocular Surface Health and Tear Film Dynamics in Patients with Dry Eye Disease: Detailed Analysis and Observations Over a 1-Year Follow-Up Period

Pac,

Munteanu,

Sánchez-González

et al. 2024

Ophthalmol Ther

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Introduction To evaluate the long-term effects of intense pulsed light (IPL) therapy on patients with dry eye disease (DED) associated with meibomian gland dysfunction (MGD). Methods A retrospective case series was performed with 110 participants undergoing IPL therapy. Assessments included the eye fitness test (EFT) to gauge subjective symptoms, along with objective measures using the Tearcheck ® device (ESW Vision, Houdan, France) noninvasive first breakup time (NIFBUT), noninvasive average breakup time (NIABUT), central tear meniscus height (CTMH), thinnest tear meniscus height (TTMH), and ocular surface inflammatory risk evaluation (OSIE) assessed using the SCHWIND SIRIUS device (SCHWIND eye-tech-solutions GmbH, Kleinostheim, Germany). Results This study documented significant improvements in subjective and objective symptoms associated with DED and MGD. Subjective symptoms measured by the EFT showed an average increase of 9.74 points (range −10 to 28, standard deviation [SD] ± 7.54), indicating reduced symptoms. Objective measures of tear film stability, represented by NIABUT, increased by an average of 4.04 s (range −15.00 to 14.40, SD ± 4.91). Tear film stability evaluation (TFSE) scores decreased by 229.12 points on average (range −1775 to 528, SD ± 384.94), suggesting enhanced tear film stability. OSIE type 1 showed a reduction in inflammation, with a percentage decrease of 4.98% (range −45 to 5, SD ± 7.33). Additionally, OSIE capture time decreased by 3.25 s on average (range −27 to 22, SD ± 10.35), further indicating an improvement in ocular surface health. Conclusion IPL therapy was shown to be a promising, noninvasive approach for improving quality of life in patients with DED by effectively managing symptoms and stabilizing tear film. The findings support the use of IPL as a sustainable treatment modality for DED associated with MGD.

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Intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD)–related dry eye disease (DED): a systematic review and meta-analysis

Cited by 5 publications

References 26 publications

One-year outcome of intense pulsed light therapy for refractory meibomian gland dysfunction in patients continuously exposed to hypotensive agents: a comparative study

One-year outcome of intense pulsed light therapy for refractory meibomian gland dysfunction in patients continuously exposed to hypotensive agents: a comparative study

Nanosecond Pulse Generation in the C-Band Region Using Silver Sulfide as a Saturable Absorber

Long-Term Impacts of Intense Pulsed Light Therapy on Ocular Surface Health and Tear Film Dynamics in Patients with Dry Eye Disease: Detailed Analysis and Observations Over a 1-Year Follow-Up Period

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