Intense pulsed light treatment in meibomian gland dysfunction: A concise review

Tashbayev, Behzod; Yazdani, Mazyar; Arita, Reiko; Fineide, Fredrik; Utheim, Tor Paaske

doi:10.1016/j.jtos.2020.06.002

Cited by 60 publications

(69 citation statements)

References 81 publications

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“…Severe symptoms were present in 75.80% of cases before treatment, 30.6% at 2–3 weeks, and 0% at 6 months after treatment, better than 29.1% reported by Stonecipher et al 12 after treatment. Overall, the improvements in OSDI have been reported in treatments with only IPL, with or without manual expression of the meibomian glands, 9 with some exceptions. 13 …”

Section: Discussionmentioning

confidence: 85%

“…The loss area of meibomian glands didn´t change at 2–3 weeks but increased at 6 months after treatment, although remained within normal values too, whereby authors considered that the combined treatment was safe. This parameter is not consistently reported in IPL studies without LLL, 9 so no comparison is possible.…”

Section: Discussionmentioning

confidence: 99%

“…Intense pulsed light therapy (IPL) is a light-emitting system and has been reported as an effective and safe procedure in MGD. 9 The emission wavelength of IPL discharged from Xenon flash lamps, ranging from 400 to 1200 nm, is within the visible light and infrared radiation wavelength of the electromagnetic spectrum. The produced broad wavelength is considered advantageous, as it can be absorbed by a variety of chromophores, eg, melanin (400–750 nm) and hemoglobin (578 nm), to develop heat.…”

Section: Introductionmentioning

confidence: 99%

“…The produced broad wavelength is considered advantageous, as it can be absorbed by a variety of chromophores, eg, melanin (400–750 nm) and hemoglobin (578 nm), to develop heat. 9 Low-level light therapy (LLL) is a different kind of photobiomodulation. LLL therapy can be defined as the use of low-power monochromatic light from light-emitting diodes (LEDs) in the red to near-infrared wavelengths (λ= 600–1100 nm) to modulate a biological function or induce a therapeutic effect in a nondestructive and nonthermal manner, different from IPL.…”

Section: Introductionmentioning

confidence: 99%

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Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction

Marta¹,

Baptista²,

Marques³

et al. 2021

OPTH

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Purpose To analyse the clinical outcome in patients with meibomian gland dysfunction (MGD) who underwent intense pulsed light (IPL) plus low-level light therapy (LLL). Materials and Methods The prospective non-comparative study included identified by MGD patients with altered interferometry and lower loss area of the meibomian glands (LAMG), who underwent IPL plus LLL, between July 2020 and August 2020. A multimodal assessment was performed before, 2–3 weeks, and 6 months after treatment. The main outcome was lipid layer thickness (LLT) and the secondary outcomes were the ocular surface disease index (OSDI) score, presence of corneal fluorescein staining (CFS), blink rate (BR), Schirmer test (ST), tear meniscus height (TMH), tear osmolarity (OSM), non-invasive break-up time (NIBUT) and LAMG. Results This study included 62 eyes of 31 patients, 61.3% female, with a mean age of 66.94±9.08 years at the time of IPL plus LLL treatment. LLT (<0.001) grades improved 6 months after treatment. The mean OSDI score improved (p<0.001) from 45.02±21.17 (severe symptoms) to 22.35±17.68 (moderate symptoms) at 2–3 weeks and 8.24±17.9.91 (normal) at 6 months after treatment. CFS was identified in 51.6% (32/62) before and in 45.2% (28/62) 6 months (p=0.293) after treatment. ST (p=0.014) grades improved; OSM grades mild worsened (p<0.001); TMH, NIBUT and LAMG grades did not modify 6 months after treatment. No patient suffered any adverse effects. Conclusion IPL combined with LLL was effective and safe, improving the lipid layer thickness in MGD and decreasing the level of symptoms.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction

Marta¹,

Baptista²,

Marques³

et al. 2021

OPTH

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show abstract

“…The authors do not advocate IPL alone. However, multiple studies have shown the benefits of IPL in dry eye disease [23][24][25][26][27][28][29]. In the treatment of patients with acne rosacea a more formal treatment protocol with IPL as the mainstay may be indicated but for us the combination has worked best.…”

Section: Low Level Light Therapy In Combination With Intense Pulsed Light (Lllt/ipl) (N-684)mentioning

confidence: 99%

Current treatments for Meibomian Gland Dysfunction and Eye Lid Margin Disease

Stonecipher¹,

Stonecipher²,

Stonecipher³

et al. 2021

Act Sci Oph

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Importance: This study highlights the value of current therapeutic devices in the authors practice for the management of meibomian gland dysfunction (MGD) and eyelid margin disease (ELD). Background:To evaluate the effects of current therapeutic devices on clinical measures of dry eye related to MGD and ELD in patients unresponsive to previous therapies. Design:A retrospective chart review of patients treated at one site.Participants: One thousand three hundred eighty-six eyes of 711 treated patients who were documented treatment failures with previous pharmaceuticals and/or devices were included in the patient population.Methods: Treatments for MGD included: lid exfoliation, low level light therapy in combination or alone with intense pulsed light therapy (LLLT or LLLT/IPL), thermal pulsation, blink assisted thermal energy, and radiofrequency thermal energy all performed at one center. Main Outcome Measures:Results included changes in the graded MGD score (grading scale 0 -4), tear breakup time (TBUT), Ocular Surface Disease Index (OSDI) questionnaire score and lissamine green staining (LGS).Results: Significant improvements in the MGD scores, TBUT, OSDI questionnaire scores and LGS were seen. There were no ocular or facial adverse events or side effects related to any of the treatments. Conclusion:The application of an algorithm for the treatment of MGD and ELD is beneficial in the majority of patients who had failed to improve with alternative pharmaceutical and device interventions.

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Ocular Surface Anatomy and Physiology

Douglas

2023

Pediatric Ocular Surface Disease

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Intense pulsed light treatment in meibomian gland dysfunction: A concise review

Cited by 60 publications

References 81 publications

Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction

Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction

Current treatments for Meibomian Gland Dysfunction and Eye Lid Margin Disease

Ocular Surface Anatomy and Physiology

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