Intense Raman scattering on hybrid Au/Ag nanoplatforms for the distinction of MMP-9-digested collagen type-I fiber detection

Sivashanmugan, Kundan; Liao, Jiunn Der; Shao, Pei‐Lin; Liu, Bernard Haochih; Tseng, Te Yu; Chang, Ching‐Ping

doi:10.1016/j.bios.2015.04.091

Cited by 20 publications

(2 citation statements)

References 61 publications

(137 reference statements)

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“…However, it is important to note that the size of the AgNPs model was the same in both cases. In this sense, it has been reported that the reactivity of the AgNPs can vary with respect to particle size; for example, only small decahedral structures exhibit superior catalytic activity compared with cubooctahedral structures [39,40,[42][43][44]. In this case, the experimental results observed by TEM images indicate that, in AgNPs-NaBH 4 sample, the cubooctahedral structures appear with major frequency and with a significant minor particle size (17 nm) with respect to the AgNPs-EG sample (40 nm).…”

Section: Dft Molecular Simulationmentioning

confidence: 99%

Comparative Study of Ag Nanostructures: Molecular Simulations, Electrochemical Behavior, and Antibacterial Effect

Ruíz-Baltazar

Reyes-López

Ordaz

et al. 2016

Journal of Nanomaterials

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Nanoparticles of Ag with different sizes and structures were obtained and studied. Two methods for reductions of Ag ions were employed, chemical reduction by sodium borohydride and ethylene glycol. Cuboctahedral and icosahedral structures were obtained. Molecular simulations were carried out in order to evaluate the reactivity of both structures. On the other hand, the electrochemical activity and antibacterial effect (E. coli) of the cuboctahedral and icosahedral structures were measured experimentally. The results obtained by molecular simulation, cyclic voltammetry, and antibacterial effect were compared and discussed in this work.

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Section: Dft Molecular Simulationmentioning

confidence: 99%

Comparative Study of Ag Nanostructures: Molecular Simulations, Electrochemical Behavior, and Antibacterial Effect

Ruíz-Baltazar

Reyes-López

Ordaz

et al. 2016

Journal of Nanomaterials

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“…In addition, although direct SERS sensing of THC from saliva is feasible, many ordinary biomolecules (e.g., protein and urea acid) or particles will disrupt direct THC SERS sensing from complex biofluid samples such as urine or blood. These biomolecules have high binding affinity to SERS substrates and induce severe interferences with strong background noise [12,[21][22][23]. Therefore, it is necessary to develop a chromatography technique in tandem with SERS sensing to detect THC from real complex biofluids.…”

Section: Introductionmentioning

confidence: 99%

Tetrahydrocannabinol Sensing in Complex Biofluid with Portable Raman Spectrometer Using Diatomaceous SERS Substrates

2019

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Using thin-layer chromatography in tandem with surface-enhanced Raman spectroscopy (TLC-SERS) and tetrahydrocannabinol (THC) sensing in complex biological fluids is successfully conducted with a portable Raman spectrometer. Both THC and THC metabolites are detected from the biofluid of marijuana-users as biomarkers for identifying cannabis exposure. In this article, ultra-sensitive SERS substrates based on diatomaceous earth integrated with gold nanoparticles (Au NPs) were employed to detect trace levels of cannabis biomarkers in saliva. Strong characteristic THC and THC metabolite SERS peaks at 1601 and 1681 cm−1 were obtained despite the moderate interference of biological molecules native to saliva. Urine samples were also analyzed, but they required TLC separation of THC from the urine sample to eliminate the strong influence of urea and other organic molecules. TLC separation of THC from the urine was performed by porous microfluidic channel devices using diatomaceous earth as the stationary phase. The experimental results showed clear separation between urea and THC, and strong THC SERS characteristic peaks. Principal component analysis (PCA) was used to analyze the SERS spectra collected from various THC samples. The spectra in the principal component space were well clustered for each sample type and share very similar scores in the main principal component (PC1), which can serve as the benchmark for THC sensing from complex SERS spectra. Therefore, we proved that portable Raman spectrometers can enable an on-site sensing capability using diatomaceous SERS substrates to detect THC in real biological solutions. This portable THC sensing technology will play pivotal roles in forensic analysis, medical diagnosis, and public health.

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Pyroelectrically Driven Charge Transfer and its Advantages on SERS and Self‐Cleaning Property

Wu,

Sun,

Shao

et al. 2024

Laser & Photonics Reviews

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The fabrication of reusable SERS substrates with sensitivity at the single‐molecule level remains challenging but promising. Herein, a composite surface‐enhanced Raman scattering (SERS) substrate is proposed that includes Ag nanoparticle (Ag NPs) /Graphene/BaTiO3 (Ag/G/BTO) from a chemical enhancement perspective. The pyroelectric field generated by BaTiO3 drives the charge transfer between the SERS substrate and molecules, achieving a significant improvement in the SERS performance and self‐cleaning properties. The SERS signals of rhodamine 6G (R6G) molecules are further amplified up to 70‐fold. Thus, the detection limit is reduced by three orders of magnitude in this study, reaching 10−14 m after applying a pyroelectric field. In addition, the substrate exhibits a higher degradation efficiency than previous self‐cleaning SERS substrates because of the outstanding catalytic properties of BaTiO3. Target molecules are degraded effectively after several temperature cycles. A detailed mechanism analysis of pyroelectric SERS is conducted based on theoretical simulations and experimental results. This study is considered to deepen the understanding of SERS mechanisms and boost the application of SERS technology.

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Intense Raman scattering on hybrid Au/Ag nanoplatforms for the distinction of MMP-9-digested collagen type-I fiber detection

Cited by 20 publications

References 61 publications

Comparative Study of Ag Nanostructures: Molecular Simulations, Electrochemical Behavior, and Antibacterial Effect

Comparative Study of Ag Nanostructures: Molecular Simulations, Electrochemical Behavior, and Antibacterial Effect

Tetrahydrocannabinol Sensing in Complex Biofluid with Portable Raman Spectrometer Using Diatomaceous SERS Substrates

Pyroelectrically Driven Charge Transfer and its Advantages on SERS and Self‐Cleaning Property

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