A novel high-efficiency vortex (HEV) static mixer was used to locally enhance the heat transfer coefficient of a drag-reducing fluid, Ethoquad O/12 (EO12) (3 mM) with sodium salicylate (NaSal) (5 mM). Significant enhancement of heat transfer coefficients was observed. The Nusselt numbers were three to five times those of normal drag-reducing flow without mixer and were close to those of water at high Reynolds number with only modest energy penalty. In contrast, a Helix static mixer increased Nusselt number slightly with very high pressure loss. A performance number was used for comparisons among the HEV static mixer, the Helix static mixer, and water without mixer. The HEV static mixer had a performance number comparable to that of water. The enhanced heat transfer by the HEV static mixer resulted from streamwise vortices generated by the inclined tabs, which increased the convective heat transfer in the radial direction.