Intensification of the organism detoxification ability under surgical endogenous intoxication

Vlasov, A. P.; Болотских, В. А.; Власова, Т. И.; Sheyranov, N.S.; Васильев, В. В.; Sinyavina, K. M.; Bolushev, P. O.

doi:10.17116/hirurgia201906173

Cited by 2 publications

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References 2 publications

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“…In the case of peritonitis, the values of inflammation markers increase and there is activation of oxidative stress and phospholipases. [29] In cases of duodenal ulcer perforation, leukocyte count, neutrophil ratio, and CRP values increase significantly due to inflammation or infection. [30,31] In our study, there was a similarity between primary repair and sutureless drainage groups in terms of neutrophil count.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of “primary repair” and “placing a drain without repair” methods in duodenum perforations

Karatas

Kanlıöz²,

Gokturk

et al. 2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:Duodenal ulcer perforation is a serious condition. A number of methods have been defined and used in surgical treatment. In this study, it was aimed to compare the effectiveness of "primary repair" and "drain placement without repair" methods in duodenal perforations using an animal model. METHODS:Three equivalent groups of ten rats each were formed. Perforation was created in the duodenum in the first (primary repair/sutured group) and the second group (drain placement without repair/sutureless drainage group). In the first group, the perforation was repaired with sutures. In the second group, only a drain was placed in the abdomen without sutures. In the third group (control group), only laparotomy was performed. Neutrophil count, sedimentation, serum C-reactive protein (CRP), serum total antioxidant capacity (TAC), serum total thiol, serum native thiol, and serum myeloperoxidase (MPO) analyses were performed on animal subjects in the pre-operative period and on the post-operative 1 st and 7 th days. Histological and immunohistochemical (transforming growth factor-beta 1 [TGF-β1]) analyzes were performed. Blood analysis, histological, and immunohistochemical findings obtained from the groups were compared statistically. RESULTS:There was no significant difference between the first and second groups, except for the TAC on the post-operative 7 th day and MPO values on the post-operative 1 st day (P>0.05). Although tissue healing was more pronounced in the second group than in the first group, there was no significant difference between the groups (P>0.05). TGF-β1 immunoreactivity observed in the second group was found to be significantly higher than in the first group (P<0.05). CONCLUSION:We think that the sutureless drainage method is as effective as the primary repair method in the treatment of duodenal ulcer perforation and can be safely applied as an alternative to the primary repair method. However, further studies are needed to fully determine the efficacy of the sutureless drainage method.

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Section: Discussionmentioning

confidence: 99%

“…In the case of peritonitis, the values of inflammation markers increase and there is activation of oxidative stress and phospholipases. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Comparison of “primary repair” and “placing a drain without repair” methods in duodenum perforations

Karatas

Kanlıöz²,

Gokturk

et al. 2023

Ulus Travma Acil Cerrahi Derg

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New approaches to laboratory diagnosis of liver condition in cattle

et al. 2023

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Новые подходы к лабораторной диагностике состояния печени у крупного рогатого скота РЕЗЮМЕ Актуальность. На сегодняшний день научное сообщество во всем мире проявляет значительный интерес к изучению синдрома эндогенной интоксикации организма. В статье представлены результаты оценки уровня эндогенной интоксикации при болезнях печени крупного рогатого скота по концентрации молекул средней массы в сыворотке крови.Методы. Было сформировано две группы коров по 50 голов в каждой: 1-я -здоровое поголовье; 2-я -с патологией печени. Состояние печени у коров оценивалось по клиническому статусу, границам печени и ее чувствительности, биохимическому исследованию крови и ультразвуковой диагностике гепатобилиарной системы. Уровень эндогенной интоксикации у коров изучался по двум фракциям МСМ при длинах волн λ = 254 нм (МСМ 254) и λ = 280 нм (МСМ 280).Результаты. Наиболее высокие значения маркеров эндотоксикоза в крови отмечены у коров с гепатитом. Так, достоверная разница в МСМ 254 (токсическая фракция) со здоровыми животными в этой подгруппе составила 1,8 раз, изменения фракции МСМ 280 (фракция, содержащая ароматические аминокислоты) были менее выражены -показатель повышен на 25,4 %. При гепатозе у коров уровень МСМ 280 в крови достоверно не изменялся по отношению к данным здорового поголовья, на уровне тенденции наблюдалось увеличение показателя на 10,1 %. Уровень МСМ 254 при этом достоверно повысился в 1,5 раза. Расчет ИР 280 / 254 у коров с гепатопатологией выявил снижение показателя при максимальных изменениях у животных с гепатитом; относительно здорового поголовья разница составила 30,4 % (гепатит) и 25,3 % (гепатоз).

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Intensification of the organism detoxification ability under surgical endogenous intoxication

Cited by 2 publications

References 2 publications

Comparison of “primary repair” and “placing a drain without repair” methods in duodenum perforations

Comparison of “primary repair” and “placing a drain without repair” methods in duodenum perforations

New approaches to laboratory diagnosis of liver condition in cattle

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