Intensity-effects of strengthening exercise on thigh muscle volume, pro- or anti-inflammatory cytokines, and immunocytes in the older adults: A randomized controlled trial

Heo, Seung-Jae; Jee, Yong-Seok

doi:10.1016/j.archger.2023.105136

Cited by 3 publications

(9 citation statements)

References 52 publications

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“…Among the participants, 145 were randomly assigned to the RT intervention group, while the remaining 133 were allocated to the CG. Two studies focused exclusively on female participants ( 32 , 38 ), while the other four included individuals of both genders in their samples ( 33 , 37 , 39 , 40 ). Grip strength, skeletal muscle mass, and gait speed are commonly used to identify and characterize sarcopenia.…”

Section: Resultsmentioning

confidence: 99%

“…The diagnosis of sarcopenia is determined by assessing muscle mass, which can be evaluated through Bioelectrical Impedance Analysis (BIA) or dual-energy X-ray absorptiometry (DXA). Three studies reviewed used BIA ( 32 , 37 , 40 ), and the other three used DXA to evaluate skeletal muscle mass ( 33 , 38 , 39 ) ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Only one assessment of inflammatory markers, which involved recruiting qualified healthcare workers, was considered low risk in terms of blinding of outcome assessment (32). Conversely, the remaining five studies failed to provide detailed information on the blind outcome assessment method, raising concerns (33,(37)(38)(39)(40). Finally, all six studies demonstrated low risk regarding incomplete outcome data, selective reporting, and other biases (Figure 2).…”

Section: Methodological Qualitymentioning

confidence: 99%

“…In 2024, Heo et al. ( 33 ) also reported a positive effect of a 12-week RT on factors associated with sarcopenia in older participants, such as muscle mass and inflammatory cytokines. These studies have provided the foundation for our research.…”

Section: Introductionmentioning

confidence: 99%

“…In 2018, Chen et al (32) demonstrated that an eight-week program of kettlebell exercises decreased CRP levels in older women with sarcopenia, but there were no significant differences in IL-6 or TNF-a levels. In 2024, Heo et al (33) also reported a positive effect of a 12-week RT on factors associated with sarcopenia in older participants, such as muscle mass and inflammatory cytokines. These studies have provided the foundation for our research.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Xue,

Han,

Zheng

et al. 2024

Front. Immunol.

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ObjectiveGiven the high incidence of sarcopenia among Asians, it is imperative to identify appropriate intervention methods. The International Clinical Practice Guidelines for Sarcopenia, developed by the International Conference on Sarcopenia and Frailty Research (ICFSR) task force, recommends resistance training (RT) as a primary treatment for managing sarcopenia. Inflammatory biomarkers serve as indicators of sarcopenia. However, there is currently insufficient conclusive evidence regarding the effectiveness of RT in modulating inflammatory biomarker levels among Asian participants with sarcopenia.Data sourcesFour databases were utilized for this study until October 9, 2023. This study focused on randomized controlled trials (RCTs) that examined the effects of RT on interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-10 (IL-10) about sarcopenia. This study has been registered in the PROSPERO database (CRD42024501855).ResultsThe meta-analysis included six studies from Asians involving 278 participants. The results showed a significant decrease in RT for IL-6 (weighted mean difference (WMD) = -0.73, 95% confidence interval (CI) = -1.02 to -0.44; n=5). However, no significant differences were found for TNF-α (WMD = -1.00, 95% CI = -2.47 to 0.46; n=5), CRP (WMD = -0.45, 95% CI = -1.14 to 0.23; n=3), and IL-10 (WMD = 0.13, 95% CI = -3.99 to 4.25; n=2). Subgroup analysis revealed that factors including gender selection, intervention methods, frequency, period, and duration could have a particular effect on the part of inflammatory biomarkers.ConclusionRT has been shown to reduce part of the level of inflammatory markers, specifically IL-6, in Asian sarcopenia participants. However, other inflammatory factors, such as TNF-α, CRP, and IL-10, did not show significant changes. Further research should confirm the impact of RT on these indicators and explore the potential effects of various factors on different inflammatory markers, such as diet, body composition, and medications.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=501855, identifier CRD42024501855.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodological Qualitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Xue,

Han,

Zheng

et al. 2024

Front. Immunol.

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Research Progress on the Effects of Different Exercise Modes on the Secretion of Exerkines After Spinal Cord Injury

Li,

Zhang

2024

Cell Mol Neurobiol

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Exercise training is a conventional treatment strategy throughout the entire treatment process for patients with spinal cord injury (SCI). Currently, exercise modalities for SCI patients primarily include aerobic exercise, endurance training, strength training, high-intensity interval training, and mind–body exercises. These exercises play a positive role in enhancing skeletal muscle function, inducing neuroprotection and regeneration, thereby influencing neural plasticity, reducing limb spasticity, and improving motor function and daily living abilities in SCI patients. However, the mechanism by which exercise training promotes functional recovery after SCI is still unclear, and there is no consensus on a unified and standardized exercise treatment plan. Different exercise methods may bring different benefits. After SCI, patients' physical activity levels decrease significantly due to factors such as motor dysfunction, which may be a key factor affecting changes in exerkines. The changes in exerkines of SCI patients caused by exercise training are an important and highly relevant and visual evaluation index, which may provide a new research direction for revealing the intrinsic mechanism by which exercise promotes functional recovery after SCI. Therefore, this article summarizes the changes in the expression of common exerkines (neurotrophic factors, inflammatory factors, myokines, bioactive peptides) after SCI, and intends to analyze the impact and role of different exercise methods on functional recovery after SCI from the perspective of exerkines mechanism. We hope to provide theoretical basis and data support for scientific exercise treatment programs after SCI.

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Effects of physical inactivity behavior during COVID-19 pandemic on physical fitness, body composition, inflammatory cytokine, and immunocytes in older adults: A retrospective and prospective study

Park,

Jee

2024

Physiology & Behavior

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Intensity-effects of strengthening exercise on thigh muscle volume, pro- or anti-inflammatory cytokines, and immunocytes in the older adults: A randomized controlled trial

Cited by 3 publications

References 52 publications

Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Research Progress on the Effects of Different Exercise Modes on the Secretion of Exerkines After Spinal Cord Injury

Effects of physical inactivity behavior during COVID-19 pandemic on physical fitness, body composition, inflammatory cytokine, and immunocytes in older adults: A retrospective and prospective study

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