Intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer: A dosimetric comparison

Nguyen, My‐Lien; Cantrell, J. Nathan; Ahmad, Salahuddin; Henson, Christina

doi:10.1016/j.meddos.2021.02.001

Cited by 16 publications

(14 citation statements)

References 12 publications

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“…The number of studies comparing photon and proton therapy for SNC is very limited. Nguyen et al [23] performed a dosimetric comparison of photons and protons for head and neck cancer (only one SNC patient) and found a dosimetric advantage with proton therapy, especially for contralateral structures similar to the findings in our study. Ramaekers et al [24] did a systematic review of studies comparing proton and photon treatment for head and neck cancer.…”

Section: Discussionsupporting

confidence: 89%

Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer

Perez

Sharma

Elstrøm

et al. 2022

Radiotherapy and Oncology

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Section: Discussionsupporting

confidence: 89%

Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer

Perez

Sharma

Elstrøm

et al. 2022

Radiotherapy and Oncology

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“…In view of their physical and biophysical properties, charged particle beams are ideally suited for dose escalation in complex anatomical sites located close to critical and radiosensitive organs [139]. The dosimetry advantage provided by IMPT over IMRT in HN tumors was recently demonstrated by Nguyen et al [152]. IMPT is thereby considered as the gold standard treatment for skull base radioresistant tumors, such as chordomas and chondrosarcomas, which need to be irradiated with a high dose [153][154][155].…”

Section: Definitive Particle (Chemo)radiationmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Ferrari

Taboni

Carobbio

et al. 2021

Cancers

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Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.

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“…The utilisation of IMPT for head and neck tumours is relatively new but has shown promise dosimetrically. 2 In our previous study, we compared the dosimetric characteristics of patients treated at our institution 2 and found that both IMPT and IMRT had sufficient dose coverage to the target volume. IMPT, however, had a dosimetric advantage in the majority of OARs though both IMPT and IMRT plans met OAR planning objectives.…”

Section: Introductionmentioning

confidence: 99%

Comparison of intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer based on radiobiological modelling

Nguyen¹,

Afrin

Newbury

et al. 2023

J Radiother Pract

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Aim: The aim of our study is to retrospectively report the radiobiological aspects for intensity-modulated proton therapy (IMPT) against intensity-modulated radiation therapy (IMRT) for patients with head and neck cancer treated at our institution. A secondary goal is to reinforce current model-based approaches to head and neck cancer patient selection for IMPT. Materials and Methods: Eighteen patients were evaluated with prescription doses ranging from 50 to 70 Gy delivered in 2 Gy per fraction. The dose volume histograms (DVH) were used to calculate equivalent uniform dose (EUD), tumour control probability (TCP) and normal tissue complication probability (NTCP) for biophysical comparison using mechanistic mathematical dose response models. Absolute values of TCP and NTCP were then compared between IMPT and IMRT. Results: The dose models demonstrate a minimal radiobiological advantage for IMPT compared to IMRT in treating head and neck cancers. Absolute values of TCP were slightly higher, while absolute values of NTCP were slightly lower for IMPT versus IMRT. Conclusions: Further studies are needed to determine if the radiobiological advantage indeed translates to a therapeutic advantage for patients.

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Intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer: A dosimetric comparison

Cited by 16 publications

References 12 publications

Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer

Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Comparison of intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer based on radiobiological modelling

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