“…Dose distribution comparison is performed routinely in radiotherapy-related activities, e.g., patient-specific quality assurance (QA) using 2D/3D dosimeters for intensity-modulated radiation therapy (IMRT) (Low et al 1998b, 1999, Childress et al 2002, Dogan et al 2002, Ju et al 2002, Kapulsky et al 2002, Low 2002, Olch 2002, Partridge et al 2002, Zhu et al 2002, Chang and Ling 2003, Greer and Popescu 2003, Jursinic and Nelms 2003, Leal et al 2003, Richardson et al 2003, Tangboonduangjit et al 2003, Warkentin et al 2003, Bucciolini et al 2004, Letourneau et al 2004, Van Esch et al 2004, Yeo et al 2004. This is not a trivial task due to the fact that, to be clinically relevant, we need to compare dose distributions in both dose and spatial domains (Van Dyk et al 1993, Childress et al 2002.…”