Intensity-modulated radiotherapy improves target coverage, spinal cord sparing and allows dose escalation in patients with locally advanced cancer of the larynx

Intensity‐modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx

“…[4][5][6][7][8][9][10] Scant clinical data exist, however, that evaluate the efficacy of IMRT for tumors located in the hypopharyngeal and laryngeal regions. Several small single-institution series with relatively short follow-up suggest good disease outcomes compared with historical published series, [11][12][13] with less toxicity than that observed with conventional techniques. The purpose of the current study was to build on the existing data for hypopharyngeal and laryngeal SCC treated with IMRT, with a focus on acute toxicity and disease outcomes.…”

Intensity-modulated radiotherapy in patients with head and neck cancer: a European single-centre experience

“…The sharp dose fall-off gradient of this technique permits the administration of a highly conformal and more homogeneous dose to the planning target volume (PTV) [12] than conventional and conformal radiotherapy. This allows better sparing of the organs at risk (e.g.…”

Larynx-sparing techniques using intensity-modulated radiation therapy for oropharyngeal cancer

“…With the development of the Intensity-Modulated Radiation Therapy (IMRT) technique, head and neck cancers have been treated with good results as reported by various investigators [2,3].…”

“…IMRT has been shown to offer better target homogeneity and tumor coverage and normal organ sparing [3,4]. However, the use of IMRT tends to unnecessarily deliver higher dose to the larynx [5].…”