Intensity-Modulated Radiotherapy With Concurrent Chemotherapy for Previously Irradiated, Recurrent Head and Neck Cancer

Biagioli, Matthew C.; Harvey, Mark; Roman, Eloy; Raez, Luis E.; Wolfson, Aaron H.; Mutyala, Subhakar; Han, Hyo S.; Markoe, Arnold M.

doi:10.1016/j.ijrobp.2007.04.057

Cited by 80 publications

(76 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Highly conformal radiation techniques with photons, such as intensity-modulated radiation therapy (IMRT) [2], brachytherapy [3], intraoperative radiation therapy [4], and stereotactic body radiosurgery [5,6] have been employed for retreatment in order to treat a limited tumor volume while sparing normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Proton Reirradiation of Recurrent Rectal Cancer: Dosimetric Comparison, Toxicities, and Preliminary Outcomes

Berman¹,

Both²,

Sharkoski³

et al. 2014

International Journal of Particle Therapy

View full text Add to dashboard Cite

Purpose: Locally advanced rectal adenocarcinoma is effectively treated with chemoradiation and surgery; however, 10 to 25% of patients locally recur within or near a previously irradiated field. Proton radiation therapy (PRT) is ideally suited to the problem of reirradiation for locally recurrent rectal cancer (LRRC). Patients and Methods: Seven patients with LRRC in or near prior radiation fields were enrolled on this prospective study from March 2010 to February 2011. All patients underwent positron emission tomography (PET)/computed tomography (CT) simulation and were stratified by low volume (clinical target volume,250 cm 3 , n¼4) or high volume (.250 cm 3 , n¼3). Primary endpoints were feasibility and acute toxicity (within 90 days from PRT initiation). Dosimetry was compared using the Wilcoxon signed-rank test. Tumor response was defined according to PERCIST criteria. Results: Median follow-up was 14 months (4.9-22.6). Median dose of prior RT was 5040 cGy. Mean PRT dose was 6120 cGy (RBE) (range, 4500-6480 cGy). The total dose sum of prior radiation therapy treatment and PRT was 109.8 Gy (RBE) (range, 95.4-151.2). One patient had surgery prior to and 1 after PRT. Six patients received concurrent 5-fluorouracil-based chemotherapy. Bowel volume receiving 10 and 20 Gy, and the dose to 200 and 150 cm 3 of bowel were significantly reduced. There were 3 acute grade 3 and 3 late grade 4 toxicities. Four patients were alive at time of follow-up. Six had a metabolic complete response, of whom 2 subsequently locally recurred. One had initial progressive disease. Of 6 symptomatic patients, 3 had complete pain resolution and 3 partial.Conclusions: This preliminary report indicates that PRT for LRRC provides dosimetric improvements over intensity-modulated radiation therapy, particularly to the bowel. The modest rates of acute and late toxicity as well as the preliminary outcomes of high tumor and symptom control rates are promising.

show abstract

Section: Introductionmentioning

confidence: 99%

Proton Reirradiation of Recurrent Rectal Cancer: Dosimetric Comparison, Toxicities, and Preliminary Outcomes

Berman¹,

Both²,

Sharkoski³

et al. 2014

International Journal of Particle Therapy

View full text Add to dashboard Cite

show abstract

“…In their report, even a significant survival benefit for use of IMRT compared with other radiation techniques was described. In another study on the use of IMRT (median dose 60 Gy) for reirradiation of patients with head and neck cancer, Biagioli et al 17 described a median overall survival of 18 months, but no information about locoregional-control was reported. Chua et al 24 focused on the retreatment of nasopharyngeal cancer by IMRT (median dose 54 Gy) and reached a median overall survival of 13 months with 1-year overall survival and 1-year locoregional control rates of 63% and 56%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…However, reports about the use of IMRT in recurrent head and neck cancer are rare. [15][16][17] To evaluate the clinical benefit of IMRT in this situation, we report our experience using this treatment approach for patients with recurrent head and neck cancer in our institution. In addition to the analysis of local control, survival, and acute and late toxicity, special attention was paid to the incidence of xerostomia after reirradiation dependent on the cumulative dose to the parotid glands, because of its significant impact on the patient's quality of life.…”

mentioning

confidence: 99%

Reirradiation with intensity‐modulated radiotherapy in recurrent head and neck cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Claus et al [10] reported repeat IMRT in 8 patients who had recurrent head and neck cancer; severe acute radiation reactions developed in 2 patients (grade 3 mucositis), 2 patients suffered grade 3 dysphagia, and 4 patients had grade 3 pain. Biagioli et al [11] reported that after repeat IMRT in 41 patients with recurrent head and neck cancer, grade 3 or 4 acute adverse radiation toxicities developed in 31.7%.…”

Section: Discussionmentioning

confidence: 99%

Radiosurgery for Desmoplastic Melanoma of the Head and Neck Using the Leksell Gamma Knife Perfexion Technology

Kano

Niranjan

Novotný

et al. 2009

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

A 44-year-old male developed chronic cancer pain caused by a progressive desmoplastic melanoma involving the mandibular division of the trigeminal nerve. The patient had failed local resection, conformal radiation therapy and chemotherapy, but was eligible for stereotactic radiosurgery using a new technology. Intraoperative stereotactic magnetic resonance and computed tomography imaging were fused to define the tumor volume and to create a conformal radiosurgery dose plan. The radiosurgery target volume was 8.6 ml. A marginal dose of 17 Gy at the 50% isodose was prescribed. The entire procedure was performed on an outpatient basis. The Leksell Gamma Knife® Perfexion™ technology increases the spectrum of treatable pathologies located in the cranial base and head and neck regions.

show abstract

Intensity-Modulated Radiotherapy With Concurrent Chemotherapy for Previously Irradiated, Recurrent Head and Neck Cancer

Cited by 80 publications

References 14 publications

Proton Reirradiation of Recurrent Rectal Cancer: Dosimetric Comparison, Toxicities, and Preliminary Outcomes

Proton Reirradiation of Recurrent Rectal Cancer: Dosimetric Comparison, Toxicities, and Preliminary Outcomes

Reirradiation with intensity‐modulated radiotherapy in recurrent head and neck cancer

Radiosurgery for Desmoplastic Melanoma of the Head and Neck Using the Leksell Gamma Knife Perfexion Technology

Contact Info

Product

Resources

About