“…The question was, therefore, whether this pronounced damage to the inner walls of blood vessels was the result of specific physical interactions of pions with tissues of different compositions or whether it was related to a biological effect of the LET distribution of stopped pions. Several authors (Jackson et a1 1982, Lewis et a1 1982, O'Leary 1984, O'Leary andJackson 1985, Smith J R H er a1 1986, Smith K R et a1 1986) have pointed out the importance of tissue composition regarding the absorption of energy due to different relative contributions of secondary charged particles from the capture of pions in carbon and oxygen. For example, comparing muscle and Perspex, whose C/O capture ratios are 0.12 and 1.76 respectively, the dose difference between these materials is evaluated as 5.5% for a therapeutic pion beam of 170 MeV c-' (Lewis 1985).…”