Intensive blood pressure control in patients with acute type B aortic dissection (RAID): study protocol for randomized controlled trial

Zhou, Jiancang; Zhang, Nan; Zhang, Zhong-heng; Wang, Tingting; Zhu, Yuefeng; Kang, Hui; Zhang, Weimin; Li, Donglin; Li, Weidong; Liu, Zhen-Jie; Qian, Xi-Min; Zhang, Ming-You; Wang, Jue; Zhou, Mi; Yang, Zhitao; Yu, Yunxian; Li, Hang-Yang; Zhang, Jian; Wang, Yonggang; Gao, Jianping; Ling, Lin; Pan, Kong-Han

doi:10.21037/jtd.2017.03.180

Cited by 11 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high blood pressure aggravated hematoma expansion and expanded of false lumen. Therefore, the control of blood pressure was the main treatment of ATAAD and alleviated the chest pain [20].. It was also in uenced the Renin-Angiotensin-Aldosterone System, sympathetic sensory system incitement and cytokines level, which related to the adverse events [21].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Prognostic Impact of the Metabolic Syndrome and Its Components in Acute Type A Aortic Dissection After Surgery: A 3-Year Follow-Up

Liu

Zhang

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background The aim of this study is to explore whether or to what extent the metabolic syndrome (METs) and its components was associated with poor outcome in acute type A aortic dissection patients (ATAAD) after surgery. Methods This study involved 353 ATAAD patients undergo surgery. Data on demographic and clinical characteristics were collected. Subgroup analysis, mixed models regression analysis, score systems and receiver-operating characteristic curves (ROC) analysis were done. Results Overall, 353 inpatients were assigned to the poor outcome group (n = 69) and control group (n = 284) with or without METs. Compared to control group, the incidence of METs was higher in poor outcome group. Poor outcome were present in 0%, 4.4%, 12.3%, 47.6%, 71.4% and 100% of the six groups, who met the diagnostic criteria of MetS 0, 1, 2, 3, 4 and 5 times. For multivariable logistic regression, quartiles of BMI remained the risk factors of poor outcome after adjustment other risk factors. After adjustment for potential confounding factors, METs was an independent risk factors in several models. Assigning a score of one for each components, the AUC were 0.877 (95%CI: 0.823-0.923) in all patients, 0.864 (95%CI: 0.7945-0.935) in METs and 0.700 (95%CI: 0.567-0.833) in non-METs by Receiver-operating characteristic. Conclusions METs, especially for BMI, confers greater risk for poor outcome in ATAAD after surgery during 3-year follow up.

show abstract

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Prognostic Impact of the Metabolic Syndrome and Its Components in Acute Type A Aortic Dissection After Surgery: A 3-Year Follow-Up

Liu

Zhang

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Supporting this view, analysis of the IMPROVE trial had shown that a decrease in blood pressure to 70 mmHg was associated with greater mortality [ 125 ]. It must also be noted that although there is some evidence to support the aforementioned heart rate goals [ 126 ], the evidence base for blood pressure goals is largely poor, with the ongoing RAID trial attempting to remedy this gap in the literature [ 127 ]. With respect to analgesic control, opiates are recommended to alleviate the patient’s pain and consequently reduce sympathetic stimulation, thus serving to augment heart rate and blood pressure control [ 122 ].…”

Section: Treatmentmentioning

confidence: 99%

Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances

Sayed

Munir

Bahbah

2021

CCR

View full text Add to dashboard Cite

: Aortic dissection is an emergent medical condition, generally affecting the elderly, characterized by a separation of the aortic wall layers and subsequent creation of a pseudolumen that may compress the true aortic lumen. Predisposing factors mediate their risk by either increasing tension on the wall or by causing structural degeneration. They include hypertension, atherosclerosis, and a number of connective tissue diseases. If it goes undetected, aortic dissection carries a significant mortality risk; therefore, a high degree of clinical suspicion and a prompt diagnosis are required to maximize survival chances. Imaging methods, most commonly a CT scan, are essential for diagnosis; however, several studies have also investigated the effect of several biomarkers to aid in the detection of the condition. The choice of intervention varies depending on the type of dissection, with open surgical repair remaining of choice in those with type. A dissections; however, the role of conventional open surgery has considerably diminished in complicated type B dissections, with endovascular repair, a much less invasive technique, proving more effective. In uncomplicated type B dissections, where medical choice reigned supreme as the optimal intervention, endovascular repair is being explored as a viable option which may reduce long term mortality outcomes, although the ideal intervention in this situation is far from settled.

show abstract

“…Theoretically, a much lower target may further decrease the risk of the propagation of dissection. However, some argued that very low blood pressure would compromise organ perfusion [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Extensive Aortic Dissection in a Low-Risk Male Causing Acute Kidney Injury: A Case Report

Anene

2023

Cureus

View full text Add to dashboard Cite

Aortic dissection is a major differential diagnosis in an elderly male with severe chest pain radiating to the back who has a history of hypertension, smoking, or connective tissue disorders such as Marfan and Ehlers-Danlos syndromes. It is a medical emergency with a high mortality rate if undetected and untreated. This report describes the case of a patient presenting with extensive aortic dissection with no significant risk factors who was diagnosed following a CT angiogram of the aorta. He was subsequently managed medically before being transferred for definitive surgical management with a good outcome.

show abstract

Intensive blood pressure control in patients with acute type B aortic dissection (RAID): study protocol for randomized controlled trial

Cited by 11 publications

References 16 publications

WITHDRAWN: Prognostic Impact of the Metabolic Syndrome and Its Components in Acute Type A Aortic Dissection After Surgery: A 3-Year Follow-Up

WITHDRAWN: Prognostic Impact of the Metabolic Syndrome and Its Components in Acute Type A Aortic Dissection After Surgery: A 3-Year Follow-Up

Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances

Extensive Aortic Dissection in a Low-Risk Male Causing Acute Kidney Injury: A Case Report

Contact Info

Product

Resources

About