Intensive care admission for Coronavirus OC43 respiratory tract infections

Vandroux, David; Allou, Nicolas; Jabot, Julien; Yuen, George; Brottet, Elise; Roquebert, Bénédicte; Martinet, Olivier

doi:10.1016/j.medmal.2018.01.001

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…CoV-NL63 has recently been described to cause a fatal outbreak of SARI in a long-term care facility with a 27.7% infection rate and 1.5% lethality in Baton Rouge, Louisiana, USA [33]. Reports on hospital outbreaks of CoV-OC43 and CoV-HKU1 are scanty, and infections by these CoVs resulting in SARI are typically seen in frail subjects [34,35]. The propensity for nosocomial spreading and the dominant role played by symptomatic patients in the spreading of the infection are supported by basic virology.…”

Section: Hospital Outbreaks Of Non-sars-like Covsmentioning

confidence: 99%

Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses

Raoult¹,

Zumla²,

Locatelli³

et al. 2020

CST

341

284

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Coronaviruses (CoVs) are a large family of enveloped, positivestrand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and account for a substantial fraction of upper respiratory tract infections. Non-SARS-like CoV can occasionally produce severe diseases in frail subjects but do not cause any major (fatal) epidemics. In contrast, SARS like CoVs (namely SARS-CoV and Middle-East respiratory syndrome coronavirus, MERS-CoV) can cause intense short-lived fatal outbreaks. The current epidemic caused by the highly contagious SARS-CoV-2 and its rapid spread globally is of major concern. There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe with two consequences: (i) clusters of severe infections among frail subjects could haphazardly occur linked to unrecognized index cases; (ii) the current epidemic could naturally fall into a low-level endemic phase when a significant number of subjects will have developed immunity. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. Whilst the future evolution of this epidemic remains unpredictable, classic public health strategies must follow rational patterns. The emergence of yet another global epidemic underscores the permanent challenges that infectious diseases pose and underscores the need for global cooperation and preparedness, even during inter-epidemic periods.

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Section: Hospital Outbreaks Of Non-sars-like Covsmentioning

confidence: 99%

Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses

Raoult¹,

Zumla²,

Locatelli³

et al. 2020

CST

341

284

View full text Add to dashboard Cite

show abstract

“…We have previously shown that the presence of coronavirus OC43 N-protein in the nasopharynx correlates with the respiratory tract infection symptoms 32 . It has been shown that clinical presentations of seasonal coronavirus OC43 infections can be similar to those of coronaviruses that are considered as severe viruses (SARS and MERS) 33 .…”

Section: Introductionmentioning

confidence: 99%

Clinical validation of automated and rapid mariPOC SARS-CoV-2 antigen test

Antikainen¹,

Hotakainen

Haveri

et al. 2021

Sci Rep

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COVID-19 diagnostics was quickly ramped up worldwide early 2020 based on the detection of viral RNA. However, based on the scientific knowledge for pre-existing coronaviruses, it was expected that the SARS-CoV-2 RNA will be detected from symptomatic and at significant rates also from asymptomatic individuals due to persistence of non-infectious RNA. To increase the efficacy of diagnostics, surveillance, screening and pandemic control, rapid methods, such as antigen tests, are needed for decentralized testing and to assess infectiousness. A novel automated mariPOC SARS-CoV-2 test was developed for the detection of conserved structural viral nucleocapsid proteins. The test utilizes sophisticated optical laser technology for two-photon excitation and individual detection of immunoassay solid-phase particles. We validated the new method against qRT-PCR. Sensitivity of the test was 100.0% (13/13) directly from nasopharyngeal swab specimens and 84.4% (38/45) from swab specimens in undefined transport mediums. Specificity of the test was 100.0% (201/201). The test's limit of detection was 2.7 TCID50/test. It showed no cross-reactions. Our study shows that the new test can detect infectious individuals already in 20 min with clinical sensitivity close to qRT-PCR. The mariPOC is a versatile platform for syndromic testing and for high capacity infection control screening of infectious individuals.

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“…Coronaviridae represent a very important family of animal and human viruses [1,2] that are in permanent circulation. Four common human coronaviruses (HKU1, NL63, OC43 and E229) cause 10-20% of respiratory infections worldwide and are present in all continents [3][4][5][6][7][8][9][10][11][12][13][14] ( Table 1). Mortality is poorly assessed, but it is clear that there are chronic carriers as well as asymptomatic carriers.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2: fear versus data

Roussel

Giraud-Gatineau

Jimeno

et al. 2020

International Journal of Antimicrobial Agents

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Highlights Comparison of incidence and mortality rates of four common coronaviruses circulating in France with those of SARS-COV-2 in OECD countries. As of 2 March 2020, 90 307 patients had tested positive for SARS-CoV-2 worldwide, with 3086 deaths (mortality rate 3.4%). As of 2 March 2020, among OECD countries, 7476 patients had tested positive for SARS-CoV-2, with 96 deaths (mortality rate 1.3%)  As of 2 March 2020, in France, 191 people had tested positive for SARS-CoV-2, with three deaths (mortality rate 1.6%). In OECD countries. the mortality rate for SARS-CoV-2 (1.3%) is not significantly different from that for common coronaviruses identified at the study hospital in France (0.8%; P=0.11). The problem of SARS-CoV-2 is probably overestimated, as 2.6 million people die of respiratory infections each year compared with less than 4000 deaths for SARS-CoV-2 at the time of writing. ABSTRACT SARS-CoV-2, the novel coronavirus from China, is spreading around the world, causing a huge reaction despite its current low incidence outside China and the Far East. Four common coronaviruses are in current circulation and cause millions of cases worldwide. This article compares the incidence and mortality rates of these four common coronaviruses with those of SARS-COV-2 in Organisation for Economic Co-operation and Development countries. It is concluded that the problem of SARS-CoV-2 is probably being overestimated, as 2.6 million people die of respiratory infections each year compared with less than 4000 deaths for SARS-CoV-2 at the time of writing.

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Intensive care admission for Coronavirus OC43 respiratory tract infections

Abstract: As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.

Cited by 8 publications

References 8 publications

Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses

Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses

Clinical validation of automated and rapid mariPOC SARS-CoV-2 antigen test

SARS-CoV-2: fear versus data

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