Intensive HF-rTMS treatment in refractory medication-resistant unipolar depressed patients

Baeken, Chris; Vanderhasselt, Marie‐Anne; Remue, Jonathan; Herremans, Sarah; Vanderbruggen, Nathalie; Zeeuws, Dieter; Santermans, Liesbeth; Raedt, Rudi De

doi:10.1016/j.jad.2013.07.008

Cited by 115 publications

(98 citation statements)

References 35 publications

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“…The therapeutic benefit in depression was found to be higher for a higher number of sessions (Lam, Chan, Wilkins‐Ho, & Yatham, ) or for more than 10 sessions (Gershon, Dannon, & Grunhaus, ). Multiple rTMS sessions per day may also be a promising therapeutic development, as recently shown in depression (Baeken et al, ). Also, we have only used behavioural measures that may be not sensitive enough.…”

Section: Discussionmentioning

confidence: 99%

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A Lack of Clinical Effect of High‐frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double‐blind Trial

Gay

Jaussent

Sigaud

et al. 2016

Euro Eating Disorders Rev

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Studies suggest that stimulation of the left dorsolateral prefrontal cortex (DLPFC) reduces food craving in bulimic patients, but evidence supporting repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool is lacking. We investigated the safety and therapeutic efficacy of an adjunct high-frequency rTMS programme targeting the left DLPFC. Forty-seven women with bulimia nervosa were randomised to a real or sham stimulation group. The real group underwent 10 rTMS sessions, each consisting of 20 trains of 5 seconds with 55-second intervals between trains, at a frequency of 10 Hz. The main outcome was the number of binge episodes in the 15 days following the end of stimulation. Overall, no significant improvement in bingeing and purging symptoms was noted after the programme. rTMS was well tolerated. This suggests that 10 sessions of high-frequency rTMS to the left DLPFC provide no greater benefit than placebo. Future studies should consider methodological issues as well as alternative targets. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.

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Section: Discussionmentioning

confidence: 99%

“…Gay et al (Gershon, Dannon, & Grunhaus, 2003). Multiple rTMS sessions per day may also be a promising therapeutic development, as recently shown in depression (Baeken et al, 2013). Also, we have only used behavioural measures that may be not sensitive enough.…”

Section: Discussionmentioning

confidence: 99%

A Lack of Clinical Effect of High‐frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double‐blind Trial

Gay

Jaussent

Sigaud

et al. 2016

Euro Eating Disorders Rev

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“…Studies in pregnant women with depression reported using 10-25 Hz in the left DLPFC and 1 Hz in the right DLPFC, which are very similar to the frequencies used in depression protocols in non-pregnant adults. [40][41][42][43][44] The number of sessions ranged from one session every undergone TMS during pregnancy, which reported preliminary results of no statistically significant difference in neurodevelopmental parameters when compared to a control group. 26 In that study, Eryilmaz et al confirmed that rTMS exposure during pregnancy was not associated with poorer cognitive or motor development outcomes in children aged 18-62 months.…”

Section: Fetal Outcomesmentioning

confidence: 99%

Transcranial magnetic stimulation for treatment of major depression during pregnancy: a review

Felipe

Ferrão

2016

Trends Psychiatry Psychother.

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Introduction: Pregnancy is characterized by a high prevalence of mental disorders. Depression is the most common of these disorders and it is a risk factor for negative maternal and child development outcomes. Psychotherapy and pharmacotherapy are conventional and well-established therapeutic options, but some clients fail to respond and the safety of using some pharmacological agents during pregnancy is unclear. Some neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), have been studied in depressed pregnant women. Objective: To evaluate the safety and efficacy of rTMS for major depression in pregnant women. Methods: The LILACS and PubMed databases were reviewed using the search terms depression, pregnancy and magnetic stimulation. Texts including primary data, published in Portuguese, Spanish, or English, between 1995 and2014, that evaluated depressed pregnant women and used rTMS as the intervention were selected. Papers lacking sufficient data were excluded. Twenty-two texts were initially identified; after applying the inclusion criteria, 12 were selected and analyzed. Results: The studies reviewed reported satisfactory responses to rTMS in acute depressive episodes, as measured using depressive symptom scales. Remission of symptoms was achieved in many cases. The procedure was well tolerated and there were no reports of damage/complications to unborn children. Conclusion:The data available at this time support the efficacy and tolerability of rTMS for depression in pregnant women. Controlled studies should corroborate this conclusion. This review only included studies in three languages and the resulting sample size was not large enough to conduct a meta-analysis.

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“…Left prefrontal high-frequency rTMS has shown to be an effective and safe treatment in adult MDD patients documented as medication resistant (Pascual-Leone, Rubio, Pallardó, & Catalá, 1996;George et al 2010;George, Taylor, & Baron Short, 2013;Padberg & George, 2009;Baeken et al, 2013;Loo, McFarquhar, & Mitchell, 2008). Left prefrontal high-frequency rTMS has shown to be an effective and safe treatment in adult MDD patients documented as medication resistant (Pascual-Leone, Rubio, Pallardó, & Catalá, 1996;George et al 2010;George, Taylor, & Baron Short, 2013;Padberg & George, 2009;Baeken et al, 2013;Loo, McFarquhar, & Mitchell, 2008).…”

mentioning

confidence: 99%

“…frequency rTMS, delivering pulses at a frequency higher than 5 Hz, is currently FDA approved as treatment for patients with medication resistant major depressive disorder (MDD), which is approximately one-third of all MDD patients. Left prefrontal high-frequency rTMS has shown to be an effective and safe treatment in adult MDD patients documented as medication resistant (Pascual-Leone, Rubio, Pallardó, & Catalá, 1996;George et al 2010;George, Taylor, & Baron Short, 2013;Padberg & George, 2009;Baeken et al, 2013;Loo, McFarquhar, & Mitchell, 2008). The rationale to stimulate these parts of the cortex is based on earlier studies showing clear involvement of the prefrontal cortex (PFC) in the pathophysiology of MDD (Koenigs & Grafman, 2009).…”

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confidence: 99%

Focal application of accelerated iTBS results in global changes in graph measures

Klooster

Franklin

Besseling

et al. 2018

Human Brain Mapping

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Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication‐resistant depressed patients. Anatomical and resting‐state functional MRI (rs‐fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole‐brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.

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Intensive HF-rTMS treatment in refractory medication-resistant unipolar depressed patients

Cited by 115 publications

References 35 publications

A Lack of Clinical Effect of High‐frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double‐blind Trial

A Lack of Clinical Effect of High‐frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double‐blind Trial

Transcranial magnetic stimulation for treatment of major depression during pregnancy: a review

Focal application of accelerated iTBS results in global changes in graph measures

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