Intensive hormone monitoring in women with unexplained infertility: evidence for subtle abnormalities suggestive of diminished ovarian reserve

Leach, Richard E.; Moghissi, Kamran S.; Randolph, John F.; Reame, Nancy E.; Blacker, C. P.; Ginsburg, Kenneth A.; Diamond, Michael P.

doi:10.1016/s0015-0282(97)00222-7

Cited by 54 publications

(48 citation statements)

References 20 publications

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“…In this context, a recent study demonstrated higher basal FSH levels in unexplained infertility compared with fertility-proven women, a finding suggesting a subtle diminution of ovarian reserve as one of the etiologic factors in unexplained infertility [13]. A more recent study shows that higher basal FSH levels in women with imminent ovarian failure are associated with larger amplitudes of FSH pulses and greater responses of FSH to GnRH [14].…”

Section: Resultsmentioning

confidence: 97%

Is an Elevation in Basal Follicle-Stimulating Hormone Levels in Unexplained Infertility Predictive of Fecundity Regardless of Age?

et al. 2001

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Abstract.An elevation in follicle-stimulating hormone (FSH) levels is considered to reflect lowered ovarian function, resulting in poor fecundity in infertile women. However, it remains to be clarified whether or not the significance of FSH levels applies equally to all women irrespective of age. The objective of the present study is to compare basal FSH levels in infertile women who conceived or not after stratification by age. A total of 144 infertile women between ages 25 and 45 who underwent infertility treatment due to unexplained infertility in the University of Tokyo Hospital were included in the retrospective study. Subjects were divided by age into two groups, <38 (n=98) vs?38 (n=46) years, with ages ranging from 25 to 37, and from 38 to 45, respectively. Blood samples were collected in early follicular phase (day 4-6) for assessment of basal levels of LH, FSH, and PRL. In the older group, pregnant cases had significantly lower FSH levels (6.07±2.83 mIU/ml) than nonpregnant cases (9.60±3.67 mIU/ml), whereas no difference in basal FSH levels was observed between pregnant and nonpregnant cases in the younger group. Basal FSH levels of pregnant cases in the older group were significantly lower than those of pregnant cases in the younger group (8.26±2.95 mIU/ml).Basal LH and PRL levels were not related to fecundity in either group. Thus, an increase in basal FSH levels as a predictor of fecundity should be considered in the context of age.

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Section: Resultsmentioning

confidence: 97%

Is an Elevation in Basal Follicle-Stimulating Hormone Levels in Unexplained Infertility Predictive of Fecundity Regardless of Age?

et al. 2001

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“…One reason for subfertility of these patients may be diminished ovarian reserve (33). Our study focused on female age, cycle length, and basal FSH as markers for ovarian aging.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value and Clinical Impact of Basal Follicle-Stimulating Hormone in Subfertile, Ovulatory Women

Steeg

Steures

Eijkemans

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context: Basal FSH is a marker for ovarian reserve. Objectives:The objective of the study was to investigate the predictive value of basal FSH on spontaneous ongoing pregnancy in subfertile ovulatory women.Design: This was a prospective cohort study. Setting:The study was conducted in 19 fertility centers in The Netherlands.Participants: Subfertile ovulatory women without two-sided tubal pathology and in whom the man had normal sperm parameters (total motile count Ն 3 ϫ10 6 ) participated in the study. Interventions:Interventions included a fertility work-up, including a basal FSH measurement on cycle d 3.Main Outcome Measures: Spontaneous ongoing pregnancy was measured. Results

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“…FSH and LH abnormalities may reflect a dysfunction in the pituitaryovarian axis [140]. Furthermore, serum estradiol levels in the follicular phase and the estradiol/progesterone ratio have been shown to be elevated in that group [138,141]. An absent midcycle elevation of prolactin has been demonstrated in women with unexplained infertility [142].…”

Section: Oxidative Stress and Endocrinological Abnormalitiesmentioning

confidence: 99%

“…An absent midcycle elevation of prolactin has been demonstrated in women with unexplained infertility [142]. The luteal phase was impaired in 30 % of women with the presence of shorter luteal phase or decreased peak serum estradiol [138,141]. Abnormal follicular LH pulse frequency or decreased midfollicular FSH level have been reported to induce an impaired luteal phase which may be related to functional imbalance in the hypothalamus [143].…”

Section: Oxidative Stress and Endocrinological Abnormalitiesmentioning

confidence: 99%

Oxidative Stress in Unexplained Female Infertility

Verit

2015

Unexplained Infertility

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Intensive hormone monitoring in women with unexplained infertility: evidence for subtle abnormalities suggestive of diminished ovarian reserve

Cited by 54 publications

References 20 publications

Is an Elevation in Basal Follicle-Stimulating Hormone Levels in Unexplained Infertility Predictive of Fecundity Regardless of Age?

Is an Elevation in Basal Follicle-Stimulating Hormone Levels in Unexplained Infertility Predictive of Fecundity Regardless of Age?

Predictive Value and Clinical Impact of Basal Follicle-Stimulating Hormone in Subfertile, Ovulatory Women

Oxidative Stress in Unexplained Female Infertility

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