Intensive outpatient adjuvant therapy for breast cancer: results of dose escalation and quality of life.

Swain, Sandra M.; Rowland, Julia H.; Weinfurt, Kevin P.; Berg, Christine D.; Lippman, M. E.; Walton, Leslie A.; Egan, Elizabeth; King, Dorothy; Spertus, Ilyse L; Honig, Susan Flamm

doi:10.1200/jco.1996.14.5.1565

Cited by 34 publications

(18 citation statements)

References 20 publications

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“…In the study by Cinar et al (2009), the hemodialysis patients had a mean score of 68.94±14.77. In another study by Swain (1996), the patients with breast cancer had a mean score of 51.46±9.97 .The mean scores revealed by the present study are in parallel with those of similar studies, which might be attributed to the idea that human beings, who are bio-psycho-social creatures, produce similar reactions to illness across cultures.…”

Section: Discussionsupporting

confidence: 86%

Effect of Perceived Social Support on Psychosocial Adjustment of Turkish Patients with Breast Cancer

Rızalar

Özbaş²,

Akyolcu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aims: To identify the psychosocial adjustment of Turkish patients with breast cancer and the effects of perceived social support on their adjustment. Materials and Methods: The sample comprised 100 volunteering patients diagnosed with breast cancer in the last six months reporting to the Outpatient Chemotherapy Unit at the Medical Faculty Hospital in northern Turkey. The data for the study were collected through the Descriptive Information Form, the Psychosocial Adjustment to Illness Scale-Self-reflection (PAIS-SR) and the Cancer-Specific Social Support Scale and analyzed via SPSS 16.0 for Windows. Descriptive statistics, Chi square test, ANOVA and correlation were used to evaluate data. Results: There was a negative significant correlation between mean scores in the sub-scales of the social support scale and the ones in the sub-scales of the psychosocial adjustment to illness scale (p<0.05). Similarly, there was a negative significant correlation between confidence support and health care orientation as well as adjustment to social environment. Likewise, emotional support was in a negative significant correlation with health care orientation, adjustment to domestic environment, extended family relationships and adjustment to social environment. Conclusions: It was concluded that social support for patients with breast cancer had an influence on their psychosocial adjustment to illness. Holistic care should be given to breast cancer patients by oncology nurses especially in the first six months of treatment. It could be concluded that patients should be accompanied by their family/relatives in treatment and care following their diagnosis with breast cancer, that their family should be made more aware of the fact that the patient should be physically and psychologically supported, that patients with breast cancer should be provided with domiciliary care, and that they should be encouraged to participate in social support groups.

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Section: Discussionsupporting

confidence: 86%

Effect of Perceived Social Support on Psychosocial Adjustment of Turkish Patients with Breast Cancer

Rızalar

Özbaş²,

Akyolcu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However, it can be noted that the incidence of severe neutropenia, thrombopenia and febrile neutropenia did not increase from cycle 1 to cycle 4. In previously published studies of high-dose doxorubicin-cyclophosphamide regimen with rG-CSF but without stem cell transplantation (Shipp et al, 1995;Swain et al, 1996), thrombocytopenia is generally the dose-limiting toxicity, this appears to be cumulative and increases significantly between the first and last cycle (Shipp et al, 1995). These toxicities occur in the same range of doses as those used in our study: cyclophosphamide 2000 mg m -2 ; doxorubicin 40 mg m -2 every 2 weeks (Swain et al, 1996); cyclophosphamide 4000 mg m -2 ; doxorubicin 70 mg m -2 every 3 weeks for 4 cycles (Shipp et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…The use of haematopoietic growth factors and/or peripheral stem cells allows regimen to be designed (Basser et al, 1995;Swain et al, 1996;Shipp et al, 1995;Stoppa et al, 1997;Viens et al, 1997) in which dose and dose intensity are significantly increased. These can then be given safely, as out patient first-line treatment with the objective of improving chemotherapy response and disease prognosis in the whole patient population.…”

mentioning

confidence: 99%

First-line high-dose sequential chemotherapy with rG-CSF and repeated blood stem cell transplantation in untreated inflammatory breast cancer: toxicity and response (PEGASE 02 trial)

et al. 1999

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Despite the generalization of induction chemotherapy and a better outcome for chemosensitive diseases, the prognosis of inflammatory breast cancer (IBC) is still poor. In this work, we evaluate response and toxicity of high-dose sequential chemotherapy with repeated blood stem cell (BSC) transplantation administered as initial treatment in 100 women with non-metastatic IBC. Ninety-five patients (five patients were evaluated as non-eligible) of median age 46 years (range 26–56) received four cycles of chemotherapy associating: cyclophosphamide (C) 6 g m −2 – doxorubicin (D) 75 mg m −2 cycle 1, C: 3 g m −2 – D: 75 mg m −2 cycle 2, C: 3 g m −2 – D: 75 mg m −2 – 5 FU 2500 mg m −2 cycle 3 and 4. BSC were collected after cycle 1 or 2 and reinfused after cycle 3 and 4. rG-CSF was administered after the four cycles. Mastectomy and radiotherapy were planned after chemotherapy completion. Pathological response was considered as the first end point of this trial. A total of 366 cycles of chemotherapy were administered. Eighty-seven patients completed the four cycles and relative dose intensity was respectively 0.97 (range 0.4–1.04) and 0.96 (range 0.25–1.05) for C and D. Main toxicity was haematological with febrile neutropenia ranging from 26% to 51% of cycles; one death occurred during aplasia. Clinical response rate was 90% ± 6%. Eighty-six patients underwent mastectomy in a median of 3.5 months (range 3–9) after the first cycle of chemotherapy; pathological complete response rate in breast was 32% ± 10%. All patients were eligible to receive additional radiotherapy. High-dose chemotherapy with repeated BSC transplantation is feasible with acceptable toxicity in IBC. Pathological response rate is encouraging but has to be confirmed by final outcome. © 1999 Cancer Research Campaign

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“…Data from Epping-Jordan et al (1999), for example, suggested that upward of 80% of patients report low distress as they cope with cancer treatments and recover. Thus, researchers might consider including, rather than excluding, those with premorbid conditions, particularly depressive or anxiety disorders, as well as including only those with moderate to high levels of distress.…”

Section: Patient Variablesmentioning

confidence: 99%

Biobehavioral outcomes following psychological interventions for cancer patients.

Andersen¹

2002

Journal of Consulting and Clinical Psychology

188

132

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Psychological interventions for adult cancer patients have primarily focused on reducing stress and enhancing quality of life. However, there has been expanded focus on biobehavioral outcomeshealth behaviors, compliance, biologic responses, and disease outcomes-consistent with the Biobehavioral Model of cancer stress and disease course. The author reviewed this expanded focus in quasi-experimental and experimental studies of psychological interventions, provided methodologic detail, summarized findings, and highlighted novel contributions. A final section discussed methodologic issues, research directions, and challenges for the coming decade.Cancer remains a significant national problem, with over 1 million Americans diagnosed each year. The adjustment process for cancer survivors may be burdensome and lengthy, and deteriorations in quality of life are underscored if they also have adverse health effects. A previous review noted the significant quality-of-life gains that can be achieved with psychological interventions (Andersen, 1992), a conclusion echoed here. In this review, I look more broadly and include biobehavioral responses and disease outcomes as areas important for intervention efforts. Although there are proportionately fewer studies that have included the latter, multimodal interventions and assessment of psychological, behavioral, and biologic mechanisms are the pathways for future research.The Biobehavioral Model of cancer stress and disease course (Andersen, Kiecolt-Glaser, & Glaser, 1994) provides the organizational framework for the discussion. Represented in Figure 1, the model includes psychological (e.g., stress and quality of life), behavioral (e.g., health behaviors and compliance), and biologic (e.g., neuroendocrine and immune) components and specifies the pathways by which health outcomes (e.g., disease endpoints-recurrence, disease free interval) might be affected. A complete discussion of the model is available elsewhere , as only brief summaries are provided prior to each section.Studies conducted since 1992 with adult cancer patients are reviewed; selected investigations prior to that period are included because of their importance, novelty, or absence from the earlier article focusing on quality of life (Andersen, 1992). Each component of the model is considered as an outcome following psychological interventions. Prior to each, I review descriptive findings and highlight prominent correlational investigations. For all experimental studies, accrual and retention rates and patient characteristics are provided, as these areas are in need of methodologic attention, as discussed later in the article. Although tedious at times, specific techniques of interventions are provided to enable the reader to distinguish among those with similar labels. Quasi-experimental designs are included for emerging areas. With few exceptions, all studies included psychological outcomes, but in the first section, I focus on studies with only these endpoints. Figure 1). Cancer survivors report con...

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Intensive outpatient adjuvant therapy for breast cancer: results of dose escalation and quality of life.

Abstract: A dose of CY at 2,000 mg/m2 can be administered every 2 weeks with DOX and G-CSF for eight cycles in the outpatient setting with manageable toxicity. The majority of women described levels of physical symptoms and emotional distress as tolerable during treatment.

Cited by 34 publications

References 20 publications

Effect of Perceived Social Support on Psychosocial Adjustment of Turkish Patients with Breast Cancer

Effect of Perceived Social Support on Psychosocial Adjustment of Turkish Patients with Breast Cancer

First-line high-dose sequential chemotherapy with rG-CSF and repeated blood stem cell transplantation in untreated inflammatory breast cancer: toxicity and response (PEGASE 02 trial)

Biobehavioral outcomes following psychological interventions for cancer patients.

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