Inter- and intra-subject variability in ethanol pharmacokinetic parameters: Effects of testing interval and dose

Yelland, Lisa N; Burns, Jaimi P.; Sims, Donald; Salter, Amy; White, Jason M.

doi:10.1016/j.forsciint.2007.05.011

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…A much better study was reported by Yelland et al [115] in which 12 male subjects drank a moderate dose of ethanol on four occasions. The first dose was 0.44 g/kg body weight followed by 0.70 g/kg on three subsequent days, 1, 11 and 12 weeks later.…”

Section: Dosementioning

confidence: 78%

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Jones¹

2010

Forensic Science International

168

115

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Section: Dosementioning

confidence: 78%

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Jones¹

2010

Forensic Science International

168

115

View full text Add to dashboard Cite

“…The detection limit remained 0.01 mg/L throughout the study period. BAC was measured by liquid‐injection gas chromatography, performed by two Perkin‐Elmer Autosystem gas chromatographs (Instruments A and B) (18). Samples are analyzed using both Instruments A and B with ethanol retention time at 0.9 and 0.6 min, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Samples are analyzed using both Instruments A and B with ethanol retention time at 0.9 and 0.6 min, respectively. Data were collected using TurboChrom Navigator software (18). The sample analysis is then repeated by a different analyst on a different day in line with road traffic toxicology procedure and the minimized potential instrument inferences and analyst errors.…”

Section: Materials S and Me Thodsmentioning

confidence: 99%

Methamphetamine and alcohol detection in vehicle‐driver fatalities in South Australia: A 10‐year survey (2008–2018)

O'Donovan

Lewis

Heuvel

et al. 2021

Journal of Forensic Sciences

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Motor vehicle driver fatalities (≥18 years) from the files at Forensic Science South Australia were reviewed from January 2008 to December 2018 for cases in which either positive blood sample for methamphetamine (MA) or an illegal blood alcohol concentration (BAC) >0.05g/100 ml were found. Three hundred driver deaths were found with MA detected in 28 cases (age range 21–62 years; ave. 37.8 years; M:F 23:5). Hundred and fifteen cases with a BAC > 0.05 g/100 ml were identified (age range 18–67 years; ave 35.7 years; M:F 95:20). No change was found in numbers of MA cases, although alcohol cases showed a significant decline (p < 0.001). Drunk driving‐related fatal crashes tended to occur in the evening (5 p.m. to 11 p.m.), while MA‐related fatal crashes had a longer peak extending from late evening until late morning (11 p.m. to 8 a.m.). This study has demonstrated that while roadside breath testing, legislative changes, and increased monitoring have resulted in reduced levels of drunk driving, similar safety countermeasures have had negligible effects on MA use in drivers. Continued monitoring of MA use by drivers will, therefore, be necessary to assess the possible effects, or not, of new countermeasures.

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“…In order to calibrate the model of Eq. (1), the assimilation and elimination rates values for alcohol vary inside the following confidence intervals: ∈ [0.00118, 0.0205] and ∈ [0.00462, 0.00533] (95% confidence), calculated from the outcomes of [38,39]. The results of the model calibration provide the optimal parameter values for each individual and, from them and the corresponding initial values the Ermakov-Lewis energies can be computed by Eq.…”

Section: Getting the Invariant Ermakov-lewis Energymentioning

confidence: 99%

Energy and Personality: A Bridge between Physics and Psychology

Caselles¹,

Micó²,

Amigó³

2021

Preprint

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The objective of this paper is to present a mathematical formalism that states a bridge between Physics and Psychology, concretely between analytical dynamics and personality theory in order to open new insights in this theory. In this formalism energy plays a central role. First, the short-term personality dynamics can be measured by the General Factor of Personality (GFP) response to an arbitrary stimulus. This GFP dynamical response is modelled by a stimulus-response model: an integro-differential equation. The bridge between Physics and Psychology is provided when the stimulus-response model can be formulated as a linear second order differential equation and, subsequently, reformulated as a Newtonian equation. This bridge is strengthened when the Newtonian equation is derived from a minimum action principle, obtaining the current Lagrangian and Hamiltonian functions. However, the Hamiltonian is a non-conserved energy. Then, some changes provide a conserved Hamiltonian function: the Ermakov-Lewis energy. This energy is presented, as well as the GFP dynamical response that can be derived from it. An application case is presented: an experimental design in which 28 individuals consumed 26.51 g of alcohol. This experiment provides an ordinal scale for the Ermakov-Lewis energies that predicts the effect of a single dose of alcohol.

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Inter- and intra-subject variability in ethanol pharmacokinetic parameters: Effects of testing interval and dose

Cited by 12 publications

References 28 publications

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Methamphetamine and alcohol detection in vehicle‐driver fatalities in South Australia: A 10‐year survey (2008–2018)

Energy and Personality: A Bridge between Physics and Psychology

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